循环人源素在冠状动脉疾病中较低，是人类主要心脏事件的预后生物标志物。

Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

机构信息

The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Road, Changchun, Jilin 130021, China.

出版信息

Biochim Biophys Acta Gen Subj. 2022 Jan;1866(1):130010. doi: 10.1016/j.bbagen.2021.130010. Epub 2021 Sep 12.

DOI:10.1016/j.bbagen.2021.130010

PMID:34525397

Abstract

BACKGROUND

Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).

METHODS

A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography. Serum humanin and thiobarbituric acid reactive substances (TBARS) were measured at the time of initial admission. The hospitalization data and MACE of all patients were collected.

RESULTS

Circulating humanin levels were lower in the angina group compared to controls [124.22 ± 63.02 vs. 157.77 ± 99.93 pg/ml, p < 0.05] and even lower in MI patients [67.17 ± 24.35 pg/ml, p < 0.05 vs controls] and oxidative stress marker were higher in MI patients compared to the control and angina groups [12.94 ± 4.55 vs. 8.26 ± 1.66 vs. 9.06 ± 2.47 umol/ml, p < 0.05]. Lower circulating humanin levels was an independent risk factor of MI patients. Circulating humanin levels could be used to predict MACE in angina group.

CONCLUSIONS

Lower circulating humanin levels was an independent risk factor for CAD, and a potential prognostic marker for mild CAD.

GENERAL SIGNIFICANCE

Humanin may become a new index for the diagnosis and treatment of CAD.

摘要

背景

Humanin 是一种内源性线粒体衍生肽，在氧化应激、炎症和 CAD 中发挥关键作用。在这项研究中，我们测量了不稳定型心绞痛和心肌梗死（MI）患者循环中的 Humanin 水平、氧化应激和炎症标志物，并研究了这些参数与主要不良心脏事件（MACE）之间的关系。

方法

共招募了 327 名患者，这些患者均来自吉林大学第一医院的住院部，并根据临床数据和血管造影结果分为 3 组[对照组、心绞痛组和心肌梗死组（MI）]。在初次入院时测量血清 Humanin 和硫代巴比妥酸反应物质（TBARS）的水平。收集所有患者的住院数据和 MACE。

结果

与对照组相比，心绞痛组的循环 Humanin 水平较低[124.22 ± 63.02 比 157.77 ± 99.93 pg/ml，p < 0.05]，MI 患者的水平甚至更低[67.17 ± 24.35 pg/ml，p < 0.05 比对照组]，而 MI 患者的氧化应激标志物高于对照组和心绞痛组[12.94 ± 4.55 比 8.26 ± 1.66 比 9.06 ± 2.47 umol/ml，p < 0.05]。较低的循环 Humanin 水平是 MI 患者的独立危险因素。循环 Humanin 水平可用于预测心绞痛组的 MACE。