Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Department of Biochemistry and Molecular Biology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Nutrients. 2021 Apr 13;13(4):1269. doi: 10.3390/nu13041269.
Honey has exerted a high impact in the field of alternative medicine over many centuries. In addition to its wound healing, anti-microbial and antioxidant properties, several lines of evidence have highlighted the efficiency of honey and associated bioactive constituents as anti-tumor agents against a range of cancer types. Mechanistically, honey was shown to inhibit cancer cell growth through its pro-apoptotic, anti-proliferative and anti-metastatic effects. However, the potential of honey to regulate anti-tumor immune responses is relatively unexplored. A small number of in vitro and in vivo studies have demonstrated the ability of honey to modulate the immune system by inducing immunostimulatory as well as anti-inflammatory effects. In the present review, we summarize the findings from different studies that aimed to investigate the immunomodulatory properties of honey and its flavonoid components in relation to cancer. While these studies provide promising data, additional research is needed to further elucidate the immunomodulatory properties of honey, and to enable its utilization as an adjuvant therapy in cancer.
蜂蜜在替代医学领域发挥了重要作用，已经有几个世纪的历史。除了具有伤口愈合、抗菌和抗氧化特性外，还有一些证据表明，蜂蜜及其相关生物活性成分作为抗肿瘤药物对多种癌症类型具有疗效。从机制上讲，蜂蜜通过促进细胞凋亡、抑制增殖和转移来抑制癌细胞生长。然而，蜂蜜调节抗肿瘤免疫反应的潜力还相对未知。少数体外和体内研究表明，蜂蜜通过诱导免疫刺激和抗炎作用来调节免疫系统。在本综述中，我们总结了不同研究的结果，这些研究旨在调查蜂蜜及其类黄酮成分与癌症相关的免疫调节特性。虽然这些研究提供了有希望的数据，但还需要进一步的研究来进一步阐明蜂蜜的免疫调节特性，并使其能够作为癌症的辅助治疗方法。
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