Department of Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South Panjiayuan Lane, Chaoyang District, Beijing, 100021, P. R. China.
Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P.R. China.
BMC Cancer. 2021 Sep 15;21(1):1027. doi: 10.1186/s12885-021-08737-0.
Previous research found that the cancer history of an individual's sibling may be a better indicator than that of the parents. We aim to provide recommendations for opportunistic screening for individuals whose sibling had been diagnosed with cancer.
During the physical examination in Cancer Hospital, Chinese Academy of Medical Sciences, 43,300 people were asked if they have at least two siblings who developed cancer.
A total of 1270 sibling-pairs from 766 families developed cancer, including 367 pairs of brothers (Bro-pairs), 368 pairs of sisters (Sis-pairs), and 535 pairs of brother-and-sister (BroSis-pairs). The mean ages at diagnosis of cancer for the three groups were from 58 to 62 years. More than half of Bro-pairs (55.3%) or Sis-pairs (51.1%) had cancer from the same systemic origin, and more than a quarter of Bro-pairs (28.1%) and Sis-pairs (37.2%) developed the same type of cancer. However, only 36.0% of BroSis-pairs developed cancers from the same systemic origin, and 18.9% developed the same type of cancer. In Bro-pairs and BroSis-pairs, lung cancer and digestive system cancer were the most common cancers, while in Sis-pairs, breast cancer, lung cancer, cervical cancer, liver cancer and thyroid cancer were the most common ones.
If an individual's sibling is diagnosed with cancer, the individual should consider participating in opportunistic screening annually, especially for lung cancer and digestive system cancers for both sexes. For sisters, breast cancer, cervical cancer and thyroid cancer should be screened early. Additionally, genetic services are essential for individuals who have siblings with cancer.
先前的研究发现，个体兄弟姐妹的癌症病史可能比其父母的癌症病史更能作为一个指标。我们旨在为那些有兄弟姐妹被诊断出癌症的个体提供机会性筛查的建议。
在中国医学科学院肿瘤医院的体检过程中，询问了 43300 人是否至少有两个患有癌症的兄弟姐妹。
共有来自 766 个家庭的 1270 对兄弟姐妹患有癌症，其中包括 367 对兄弟（Bro-pairs）、368 对姐妹（Sis-pairs）和 535 对兄弟和姐妹（BroSis-pairs）。三组的癌症诊断平均年龄为 58 至 62 岁。超过一半的 Bro-pairs（55.3%）或 Sis-pairs（51.1%）来自同一系统的癌症，超过四分之一的 Bro-pairs（28.1%）和 Sis-pairs（37.2%）患有相同类型的癌症。然而，只有 36.0%的 BroSis-pairs 来自同一系统的癌症，有 18.9%患有相同类型的癌症。在 Bro-pairs 和 BroSis-pairs 中，肺癌和消化系统癌症是最常见的癌症，而在 Sis-pairs 中，乳腺癌、肺癌、宫颈癌、肝癌和甲状腺癌是最常见的癌症。
如果个体的兄弟姐妹被诊断出患有癌症，该个体应考虑每年参加机会性筛查，特别是对于男女的肺癌和消化系统癌症。对于姐妹，应早期筛查乳腺癌、宫颈癌和甲状腺癌。此外，对于有癌症兄弟姐妹的个体，遗传服务是必要的。
