Branebjerg P E, Heisterberg L
Department of Obstetrics and Gynecology G, Gentofte Hospital, University of Copenhagen, Denmark.
J Perinat Med. 1987;15(6):555-8. doi: 10.1515/jpme.1987.15.6.555.
The levels of ampicillin were determined in milk and plasma of 14 lactating mothers in treatment with pivampicillin for puerperal infections and in plasma of their suckling infants. Ampicillin could not be detected in plasma of the infants, i.e. all levels were less than 0.03 micrograms/ml. Maximum levels occurred in plasma 60-120 minutes and in milk 180-240 minutes after medication. Milk-plasma ratios varied between 0.01 and 0.58. The highest level of ampicillin in milk was 1.02 micrograms/ml in a woman receiving pivampicillin tablets 700 mg t.d.s. At this level an infant can at the most ingest 0.5 mg/day. This dose is too small to cause any symptoms in the suckling infants, but allergic sensibilization through the milk is possible.
对14名因产褥感染接受匹氨西林治疗的哺乳期母亲的乳汁和血浆以及她们哺乳婴儿的血浆中的氨苄西林水平进行了测定。在婴儿血浆中未检测到氨苄西林，即所有水平均低于0.03微克/毫升。服药后60 - 120分钟血浆中出现最高水平，180 - 240分钟乳汁中出现最高水平。乳汁与血浆的比值在0.01至0.58之间变化。一名每日三次服用700毫克匹氨西林片的女性乳汁中氨苄西林的最高水平为1.02微克/毫升。在此水平下，婴儿每天最多摄入0.5毫克。该剂量太小，不会在哺乳婴儿中引起任何症状，但通过乳汁产生过敏致敏是可能的。
