Peiker G, Schröder S
Pharmazie. 1986 Nov;41(11):793-5.
In 23 women in childbed suffering from mastitis puerperalis the transport of oxacillin and ampicillin into the milk was investigated. Moreover the concentration of the antibiotics in the urine of babies nursed during therapy of their mothers with antibiotics was measured. After a regular taking (good compliance) the drug-concentrations in the serum and the milk of the mothers are higher than the minimal inhibiting concentrations necessary against the number of bacteria found in the milk. In the urine of suckling babies drug concentrations were differently high or undetectable as well. During the therapy of nursing mothers with antibiotics the milk should be misplaced.
对23名患有产褥期乳腺炎的产妇，研究了奥沙西林和氨苄西林向乳汁中的转运情况。此外，还测定了在其母亲接受抗生素治疗期间接受哺乳的婴儿尿液中抗生素的浓度。在规律服药（依从性良好）后，母亲血清和乳汁中的药物浓度高于针对乳汁中发现的细菌数量所需的最低抑菌浓度。在哺乳婴儿的尿液中，药物浓度也有高有低或无法检测到。在用抗生素治疗哺乳期母亲期间，应挤出乳汁。
