Department of Cardiology, Yancheng Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu Province, China.
Department of Treating Disease Center, Changzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, Jiangsu Province, China.
Comput Math Methods Med. 2021 Sep 3;2021:6710006. doi: 10.1155/2021/6710006. eCollection 2021.
This research is aimed at studying the effect of Angelica sinensis polysaccharide (ASP) extracted from the Lixinshui prescription on cardiac disease induced by hypertension in rats. Rat models of cardiovascular disease were established, and the associated factors were measured. The data showed that ASP treatment increased the ejection fraction and short axis shortening rate, while decreasing the LV end-diastolic diameter, LV end-systolic diameter, LV end-diastolic volume, and LV end-systolic volume in HHD rats. ASP downregulated the expression level of TGF-1, alpha-smooth muscle actin (-SMA), collagen I, fibronectin, vimentin, Bax, cleaved caspase-9, and cleaved caspase-3 and upregulated the expression level of Bcl-2 in LV of HHD rats. Meanwhile, ASP increased the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and decreased the level of malondialdehyde (MDA), tissue endogenous hydrogen peroxide (HO), and reactive oxygen species (ROS). Our findings indicated that ASP could prevent hypertensive heart disease by inhibiting myocardial fibrosis, suppressing the myocardial apoptosis, and alleviating oxidative stress.
本研究旨在研究从立新水方中提取的当归多糖（ASP）对高血压诱导的大鼠心脏病的影响。建立了心血管疾病大鼠模型，并测量了相关因素。数据显示，ASP 治疗可增加射血分数和短轴缩短率，同时降低 HHD 大鼠的 LV 舒张末期直径、LV 收缩末期直径、LV 舒张末期容积和 LV 收缩末期容积。ASP 下调了 TGF-1、α-平滑肌肌动蛋白（α-SMA）、胶原 I、纤维连接蛋白、波形蛋白、Bax、cleaved caspase-9 和 cleaved caspase-3 在 HHD 大鼠 LV 中的表达水平，同时上调了 Bcl-2 的表达水平。此外，ASP 增加了超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性，降低了丙二醛（MDA）、组织内源性过氧化氢（HO）和活性氧（ROS）的水平。我们的研究结果表明，ASP 可以通过抑制心肌纤维化、抑制心肌细胞凋亡和减轻氧化应激来预防高血压性心脏病。
