Shu Zhiming, Wu Tiantian, Shahen Mohamed, Guo Zihu, Shu Jia, Wang H E, Shar Akhtar H, Farag Mayada R, Alagawany Mahmoud, El-Hack Mohamed E Abd, Liu Chaobin
College of Life Science, Northwest A&F University, 712100, Shaanxi, Yangling, China.
Zoology Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt.
An Acad Bras Cienc. 2019 Sep 23;91(3):e20180424. doi: 10.1590/0001-3765201920180424. eCollection 2019.
Abstract: Cardiovascular diseases (CVDs) are leading causes of death in the world, owing to noticeable incidence and mortality. Traditional Chinese Medicine (TCM) SINI Decoction (SND) is used to prevent and treat CVDs, which has attracted extensive attention for its moderate and little side effects. However, the involved molecular mechanisms are exceedingly complicated and remain unclear. Systems pharmacology, as a novel approach that integrates systems biology and pharmacology plays a significant role in investigating the molecular mechanism of TCM. In systems pharmacology approach, we use to systematically uncover the mechanisms of action in Chinese medicinal formula SND as an effective treatment for CVDs, which mainly includes:1) molecular database building; 2) ADME evaluation; 3) target-fishing 4) network construction and analysis. The results show that 78 underlying valid ingredients and their corresponding 71 direct targets of SND were obtained. And SND take part in cardiomyocyte protection, blood pressure regulation, and lipid regulation module in treatment of CVDs by cooperative way. Systems pharmacology as an emerging field that investigates the molecular mechanisms of TCM through pharmacokinetic evaluation target prediction, and pathway analysis, which will facilitate the development of traditional Chinese herbs in modern medicine.
心血管疾病（CVDs）是全球主要的死亡原因，其发病率和死亡率显著。中药四逆汤（SND）用于预防和治疗心血管疾病，因其疗效温和且副作用小而受到广泛关注。然而，其涉及的分子机制极其复杂，仍不清楚。系统药理学作为一种整合系统生物学和药理学的新方法，在研究中药分子机制方面发挥着重要作用。在系统药理学方法中，我们用于系统地揭示中药方剂SND作为心血管疾病有效治疗方法的作用机制，主要包括：1）分子数据库构建；2）药物代谢动力学评价；3）靶点筛选；4）网络构建与分析。结果表明，获得了78种潜在有效成分及其对应的71个SND直接靶点。并且SND通过协同方式参与心血管疾病治疗中的心肌保护、血压调节和脂质调节模块。系统药理学作为一个新兴领域，通过药物代谢动力学评价、靶点预测和通路分析来研究中药的分子机制，这将促进传统中药在现代医学中的发展。
