Al-Lawama Manar, Badran Eman, Ghanim Noor, Irsheid Ayah, Qtaishat Hiba, Al-Ammouri Iyad, Al-Zyadneh Enas, Al-Iede Montaha, Daher Amira H, Bakri Fares G, Massad Ghada
Pediatric Department, School of Medicine, The University of Jordan, Amman, Jordan.
Division of Infectious Diseases, Department of Medicine, Jordan University Hospital, Amman, Jordan.
J Clin Med Res. 2021 Aug;13(8):420-424. doi: 10.14740/jocmr4578. Epub 2021 Aug 30.
The aim of the study was to investigate the clinical outcomes and rate of virus detection in neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers.
This prospective study included neonates born to SARS-CoV-2-positive mothers, documenting their viral polymerase chain reaction results and clinical outcomes.
Of the 130 neonates born to 122 SARS-CoV-2-positive mothers, 12% tested positive. Most (62%) neonates were delivered via cesarean section at an average gestational age of 36 weeks, with a birth weight of 2,900 g. Only 38% neonates required admission. SARS-CoV-2-positive infants were born at a significantly lower gestational age; had a significantly lower birth weight; and had significantly higher admission rates, surfactant therapy, and bradycardia than SARS-CoV-2-negative infants. There was no significant difference in mortality rates.
This study documents perinatal transmission of SARS-CoV-2. It reports for the first time the occurrence of neonatal bradycardia as a complication of maternal SARS-CoV-2 infection. Despite that, neonates born to SARS-CoV-2-positive mothers had relatively good short-term outcomes.
本研究旨在调查严重急性呼吸综合征冠状病毒2（SARS-CoV-2）阳性母亲所生新生儿的临床结局及病毒检测率。
这项前瞻性研究纳入了SARS-CoV-2阳性母亲所生的新生儿，记录他们的病毒聚合酶链反应结果及临床结局。
在122名SARS-CoV-2阳性母亲所生的130名新生儿中，12%检测呈阳性。大多数（62%）新生儿通过剖宫产分娩，平均孕周为36周，出生体重为2900克。只有38%的新生儿需要住院。与SARS-CoV-2阴性婴儿相比，SARS-CoV-2阳性婴儿的出生孕周显著更低；出生体重显著更低；住院率、表面活性剂治疗率和心动过缓发生率显著更高。死亡率无显著差异。
本研究记录了SARS-CoV-2的围产期传播。首次报告了新生儿心动过缓作为母亲SARS-CoV-2感染并发症的发生情况。尽管如此，SARS-CoV-2阳性母亲所生新生儿的短期结局相对较好。
