Children's Hospital of Richmond at VCU, Richmond, VA, USA.
Department of Child Health, School of Medicine, Cardiff University, Cardiff, UK.
Paediatr Respir Rev. 2020 Sep;35:31-37. doi: 10.1016/j.prrv.2020.06.006. Epub 2020 Jun 13.
Beginning in late 2019, a novel coronavirus labeled SARS-CoV-2 spread around the world, affecting millions. The impact of the disease on patients and on health care delivery has been unprecedented. Here, we review what is currently known about the effects of the virus and its clinical condition, Covid-19 in areas of relevance to those providing care to neonates. While aspects of pregnancy, including higher expression of the cell receptor for the virus, ACE2, could put these women at higher risk, preliminary epidemiological information does not support this. Viral carriage prevalence based on universal screening show that rates vary from 13% in "hot spots" such as New York City, to 3% in areas with lower cases. Vertical transmission risks are unknown but 3.1% of 311 babies born to mothers with Covid-19 were positive within a week of birth. The clinical description of 26 neonates <30 days of age showed no deaths and only one requiring intensive care. Risks for breast-feeding and for milk banks are discussed.
自 2019 年末以来,一种新型冠状病毒被标记为 SARS-CoV-2,在全球范围内传播,影响了数百万人。该疾病对患者和医疗保健的影响是前所未有的。在这里,我们回顾了与为新生儿提供护理相关的病毒及其临床状况(Covid-19)的已知信息。虽然妊娠的某些方面,包括对病毒细胞受体 ACE2 的更高表达,可能使这些女性面临更高的风险,但初步的流行病学信息并不支持这一点。基于普遍筛查的病毒携带率显示,其发生率从纽约市等“热点”地区的 13%到病例较少地区的 3%不等。垂直传播的风险尚不清楚,但 311 名患有 Covid-19 的母亲所生的婴儿中,有 3.1%在出生后一周内呈阳性。对 26 名 <30 天的新生儿的临床描述表明,没有死亡病例,只有一例需要重症监护。还讨论了母乳喂养和母乳库的风险。