去甲哈尔满和哈尔满与2-乙酰氨基芴衍生物的共诱变效应。
Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.
作者信息
Umezawa K, Shirai A, Matsushima T, Sugimura T
出版信息
Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30. doi: 10.1073/pnas.75.2.928.
Abstract
Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal enzymes. Harman also increased mutagenesis, althouth less so than norharman.
摘要
去甲哈尔满增强了2-乙酰氨基芴衍生物在沙门氏菌测试系统中的已知诱变性。仅在添加大鼠肝微粒体酶时，去甲哈尔满才增强了2-乙酰氨基芴、2-氨基芴和N-羟基-2-乙酰氨基芴的诱变性，而在没有微粒体酶的情况下，N-乙酰氧基-2-乙酰氨基芴的诱变性增加。哈尔满也增加了诱变作用，尽管比去甲哈尔满的作用小。
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