去甲哈尔满和哈尔满与2-乙酰氨基芴衍生物的共诱变效应。
Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.
作者信息
Umezawa K, Shirai A, Matsushima T, Sugimura T
出版信息
Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30. doi: 10.1073/pnas.75.2.928.
Abstract
Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal enzymes. Harman also increased mutagenesis, althouth less so than norharman.
摘要
去甲哈尔满增强了2-乙酰氨基芴衍生物在沙门氏菌测试系统中的已知诱变性。仅在添加大鼠肝微粒体酶时，去甲哈尔满才增强了2-乙酰氨基芴、2-氨基芴和N-羟基-2-乙酰氨基芴的诱变性，而在没有微粒体酶的情况下，N-乙酰氧基-2-乙酰氨基芴的诱变性增加。哈尔满也增加了诱变作用，尽管比去甲哈尔满的作用小。
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本文引用的文献
1
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Cancer Res. 1960 Jul;20:950-62.
2
3
Reactivity in vivo of the carcinogen N-hydroxy-2-acetylaminofluorene: increase by sulfate ion.
Science. 1970 Jan 9;167(3915):184-6. doi: 10.1126/science.167.3915.184.
4
On the sulfate ester of N-hydroxy-N-2-fluorenylacetamide as a key ultimate hepatocarcinogen in the rat.关于N-羟基-N-2-芴基乙酰胺硫酸酯作为大鼠关键最终致癌物的研究
Cancer Res. 1972 Mar;32(3):491-500.
5
6
Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.化学物质致癌作用概述——G. H. A. 克劳斯纪念讲座
Cancer Res. 1970 Mar;30(3):559-76.
7
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8
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9
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