作为移码诱变剂的致癌物：2-乙酰氨基芴及其他芳香胺类致癌物的代谢产物和衍生物
Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens.
作者信息
Ames B N, Gurney E G, Miller J A, Bartsch H
出版信息
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3128-32. doi: 10.1073/pnas.69.11.3128.
Abstract
Several carcinogenic metabolites of the carcinogen 2-acetyl-aminofluorene, especially 2-nitrosofluorene and N-hydroxy-2-aminofluorene, are potent frameshift mutagens for Salmonella typhimurium. 2-Nitrosonaphthalene, 2-nitrosophenanthrene, 4-nitroso-trans-stilbene, 4-nitrosobiphenyl, and 4-nitrosoazobenzene, all of which are metabolites or likely metabolites of carcinogenic aromatic amines, are also potent frameshift mutagens. These compounds may be frameshift mutagens of the class that intercalates into DNA and then reacts covalently with the DNA; various ultimate carcinogens may be of this type. The utility of a set of bacterial strains for detecting carcinogens as mutagens is shown.
摘要
致癌物2-乙酰氨基芴的几种致癌代谢物，特别是2-亚硝基芴和N-羟基-2-氨基芴，是鼠伤寒沙门氏菌的强效移码诱变剂。2-亚硝基萘、2-亚硝基菲、4-亚硝基反式芪、4-亚硝基联苯和4-亚硝基偶氮苯，所有这些都是致癌芳香胺的代谢物或可能的代谢物，也是强效移码诱变剂。这些化合物可能是插入DNA然后与DNA发生共价反应的那一类移码诱变剂；各种最终致癌物可能属于这种类型。展示了一组用于将致癌物检测为诱变剂的细菌菌株的效用。
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