Tang Ling, Zhang Yangyi, Deng Guisheng
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), Hunan Normal University, Changsha 410081, China.
Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, Hunan Normal University, Changsha 410081, China.
J Org Chem. 2021 Oct 1;86(19):13245-13251. doi: 10.1021/acs.joc.1c01109. Epub 2021 Sep 16.
Ag(I)-catalyzed cascade reactions involving enynone cyclization and cross-coupling with phosphorus ylides have been achieved for the first time. Subsequent treatment of the reaction mixture with I afforded the corresponding ()-α-alkenylfurans in 73-95% yields with excellent stereoselectively. A reasonable mechanism has been proposed.
首次实现了银（I）催化的涉及烯炔酮环化以及与磷叶立德交叉偶联的串联反应。随后用I处理反应混合物，以73 - 95%的产率和优异的立体选择性得到了相应的（）-α-烯基呋喃。已提出了合理的反应机理。
