Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China.
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Epigenomics. 2021 Sep;13(18):1443-1458. doi: 10.2217/epi-2021-0223. Epub 2021 Sep 16.
The aim of this study was to identify the long noncoding RNAs (lncRNAs) associated with schizophrenia (SZ) and the relationships among their expression, antipsychotic efficacy and SZ severity. The diagnostic and predictive value of nine lncRNAs, , , , , , , , and , was investigated in 48 patients with SZ before and after antipsychotic treatment. , , , , , and were individually and collectively associated with, and predictive of, SZ pathogenesis. Moreover, increased expression of plasma , and levels was reversed after 12 weeks of antipsychotic treatment, which was associated with SZ severity. Seven lncRNAs serve as novel biomarkers for SZ diagnosis and prognosis and three lncRNAs are potential therapeutic targets.
本研究旨在鉴定与精神分裂症（SZ）相关的长非编码 RNA（lncRNA），以及它们的表达、抗精神病疗效与 SZ 严重程度之间的关系。研究调查了 48 例 SZ 患者在抗精神病治疗前后 9 种 lncRNA（ 、 、 、 、 、 、 、 ）的诊断和预测价值。 、 、 、 、 、 和 单独和集体与 SZ 的发病机制相关，并具有预测性。此外，抗精神病治疗 12 周后，血浆 、 、 水平的表达升高得到逆转，这与 SZ 严重程度有关。7 种 lncRNA 可作为 SZ 诊断和预后的新型生物标志物，3 种 lncRNA 是潜在的治疗靶点。
