Papasavvas Ioannis, de Courten Christian, Herbort Carl P
Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialised Care (COS), Clinic Montchoisi Teaching Centre, Lausanne, Switzerland.
Clinic Montchoisi Teaching Centre, Lausanne, Switzerland.
J Ophthalmic Inflamm Infect. 2021 Sep 16;11(1):28. doi: 10.1186/s12348-021-00260-4.
We are reporting 3 patients who presented acute zoster ophthalmicus (HZO), an activation of varicella-zoster virus, after mRNA anti-SARS-CoV-2 vaccination, seen directly or referred to our center.
A 73-year-old woman with history of ocular sarcoidosis presented HZO in the right V1 dermatome 16 days after a single booster dose of vaccination (Pfizer BioNTech). A 69-year-old woman presented HZO in her V1 left dermatome, occurring 10 days after her first dose of Pfizer BioNTech vaccine. A 72-year-old woman with no history of autoimmune pathology, candidate for cataract surgery, presented 13 days after the first dose of a Moderna mRNA vaccine with an eruption in the left V1 dermatome. All patients presented the VZV infection after their first dose of a mRNA type of vaccine. Treatment with Valacyclovir 1000 mg × 3/ day for 7-14 days was efficient in all cases.
Vaccines have been reported in the past to trigger different types of side effects such as viral or flu-like symptoms. It is only logical to note many different side effects for SARS-CoV-2 vaccines as the population vaccinated is exceeding any other number in history. VZV is one of the more severe side effects that can, however, be treated. It is quite obvious that, as far as mRNA vaccines are concerned, and probably also other anti-SARS-CoV-2 vaccines, that the benefit of vaccination certainly outweighs the possible but very low risk of ocular side effects that can mostly be treated.
我们报告3例在接种mRNA抗SARS-CoV-2疫苗后出现急性眼带状疱疹（HZO，水痘-带状疱疹病毒激活）的患者，这些患者是直接就诊于我们中心或由其他机构转诊而来。
一名73岁有眼部结节病病史的女性，在单剂加强接种（辉瑞BioNTech疫苗）16天后，右侧V1皮区出现HZO。一名69岁女性，在接种第一剂辉瑞BioNTech疫苗10天后，左侧V1皮区出现HZO。一名72岁无自身免疫性疾病病史、拟行白内障手术的女性，在接种第一剂Moderna mRNA疫苗13天后，左侧V1皮区出现皮疹。所有患者均在接种第一剂mRNA疫苗后出现水痘-带状疱疹病毒感染。所有病例使用伐昔洛韦1000毫克×3次/天，治疗7 - 14天均有效。
过去曾报道疫苗会引发不同类型的副作用，如病毒感染或流感样症状。鉴于接种SARS-CoV-2疫苗的人群数量超过历史上任何其他疫苗接种人数，出现多种不同副作用是合乎逻辑的。水痘-带状疱疹病毒感染是较为严重的副作用之一，但可以治疗。很明显，就mRNA疫苗而言，可能其他抗SARS-CoV-2疫苗也是如此，接种疫苗的益处肯定超过眼部副作用这种可能但非常低的风险，而且这些副作用大多可以治疗。
