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[左侧三叉神经V1分支的带状疱疹后神经痛:8%辣椒素贴剂治疗成功]

[Postherpetic neuralgia of the left trigeminus nerve V1 : Successful therapy with capsaicin 8% patch].

作者信息

Kern K-U, Schwickert-Nieswandt M

机构信息

Institut für Schmerzmedizin, Schmerzpraxis Wiesbaden, Sonnenberger Str. 68, 65193, Wiesbaden, Deutschland.

出版信息

Schmerz. 2018 Dec;32(6):464-467. doi: 10.1007/s00482-018-0333-3.

DOI:10.1007/s00482-018-0333-3
PMID:30306307
Abstract

A 68-year-old patient suffered from postzoster neuralgia with severe pain of the left trigeminal nerve V1. Despite medication with gabapentin 1800 mg/d, oxacarbazepine 600 mg, tapentadol 500 mg/d, amitriptyline 20 mg as well as ambroxol 20% ointment and lidocaine patch topically, the pain reached an intensity of 8-10 on the numeric rating scale (NRS). Wearing a CPAP (continuous positive airway pressure) mask at night to treat a sleep apnea was impossible or the mask was leaking under lidocaine patch, only topical ambroxol 20% brought a certain pain relief. Lack of sleep, a strongly reduced quality of life and massive exhaustion followed quickly. Due to a fall the systemic medication could not be increased. Also lidocaine infusions with dexamethasone and supraorbitalis blockades were unsuccessful, and a ganglionic local opioid analgesia (GLOA) was anatomically not feasible. Therefore, 8 weeks after the onset of the disease, treatment with capsaicin 8% for 60 min on the face was performed. After only one week, 20-30% pain relief was achieved, sometimes even freedom from pain. Six weeks after application, the average pain during the day was only NRS 3/10 despite a considerable reduction in oral medication. Three months after the second treatment, the patient was almost pain-free during the day. Topical capsaicin 8% patch is, in our opinion, also safe and successful to use on the face with appropriate experience of the user.

摘要

一名68岁患者患有带状疱疹后神经痛,左侧三叉神经V1分布区剧痛。尽管服用加巴喷丁1800毫克/天、奥卡西平600毫克、曲马多500毫克/天、阿米替林20毫克,以及外用20%氨溴索软膏和利多卡因贴片,但疼痛在数字评分量表(NRS)上仍达到8 - 10级强度。夜间佩戴持续气道正压通气(CPAP)面罩治疗睡眠呼吸暂停是不可能的,或者面罩在利多卡因贴片下漏气,只有外用20%氨溴索带来了一定程度的疼痛缓解。睡眠不足、生活质量大幅下降和极度疲惫很快接踵而至。由于一次跌倒,无法增加全身用药剂量。此外,利多卡因与地塞米松联合输注以及眶上神经阻滞均未成功,而且从解剖学角度进行神经节局部阿片类镇痛(GLOA)也不可行。因此,在疾病发作8周后,对患者面部进行了60分钟的8%辣椒素治疗。仅一周后,疼痛缓解了20 - 30%,有时甚至完全无痛。用药六周后,尽管口服药物用量大幅减少,但白天的平均疼痛程度仅为NRS 3/10。第二次治疗三个月后,患者白天几乎无痛。我们认为,对于有适当使用经验的使用者而言,外用8%辣椒素贴片用于面部也是安全且有效的。

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