Research Unit, Institute of Ophthalmology, Conde De Valenciana Foundation. Chimalpopoca, Mexico City, Mexico.
Laboratorio De Inmunología, Centro De Investigación En Alimentación Y Desarrollo, A.c, Hermosillo, Sonora Mexico.
Ophthalmic Epidemiol. 2022 Oct;29(5):483-490. doi: 10.1080/09286586.2021.1974493. Epub 2021 Sep 16.
During the COVID-19 pandemic, healthcare workers (HCWs) are at a considerable risk of being infected with SARS-CoV-2; among them, HCWs from ophthalmology departments are more prone to develop severe symptoms. In Mexico City, the prevalence of SARS-CoV-2 infection among HCWs is 30%. The present work aims to describe the seroprevalence among HCWs at an Ophthalmological Reference Centre in Mexico City.
A self-report questionnaire, RT-PCR test and detection of serum IgG/IgM antibodies against SARS-CoV-2 were performed among HCWs at the Institute of Ophthalmology "Conde de Valenciana".
A total of 169 HCWs participated in the study. None of the participants declared severe symptoms, and only 15% showed three or more symptoms. The results showed that 32% of the participants were RT-PCR (54/169), and 20% (35/169) presented IgG antibodies against SARS-CoV-2. Thirteen percent of the RT-PCR subjects were IgG positive, and 7.6% of the RT-PCR participants were IgG positive. The presence of three or more symptoms correlated with the presence of IgG antibodies, as well as Ct values of < 32 ( < 0,05).
Most of the HCW cohort showed mild symptoms, and 69% of the RT-PCR participants did not show IgG antibodies against SARS-CoV-2. Seroprevalence was significantly associated with the presentation of COVID-19-associated symptoms.
在 COVID-19 大流行期间，医护人员（HCWs）感染 SARS-CoV-2 的风险相当大；其中，眼科部门的 HCWs 更容易出现严重症状。在墨西哥城，HCWs 中 SARS-CoV-2 感染的患病率为 30%。本研究旨在描述墨西哥城一家眼科参考中心的 HCWs 的血清阳性率。
在“Conde de Valenciana”眼科研究所对 HCWs 进行了自我报告问卷、RT-PCR 检测和 SARS-CoV-2 血清 IgG/IgM 抗体检测。
共有 169 名 HCWs 参与了这项研究。没有参与者报告严重症状，只有 15%的参与者出现了三种或三种以上的症状。结果表明，32%的参与者 RT-PCR 检测呈阳性（54/169），20%（35/169）的人对 SARS-CoV-2 产生 IgG 抗体。13%的 RT-PCR 阳性者 IgG 呈阳性，7.6%的 RT-PCR 阳性者 IgG 呈阳性。出现三种或三种以上症状与 IgG 抗体的存在以及 Ct 值<32（<0.05）相关。
大多数 HCW 队列表现出轻度症状，69%的 RT-PCR 参与者未显示针对 SARS-CoV-2 的 IgG 抗体。血清阳性率与 COVID-19 相关症状的出现显著相关。
