Habeck J O, Huckstorf C, Moritz V
Institute of Pathology, Bezirkskrankenhaus Friedrich Wolf, GDR, Karl-Marx-Stadt.
Biomed Biochim Acta. 1987;46(12):907-10.
The carotid body volumes of male spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY) and random-bred normotensive Wistar rats (NWR) were compared at the age of 16-18 weeks. SHR exhibited significantly greater absolute and relative carotid body volumes (CBV) than WKY or NWR. Furthermore, the absolute and relative CBV in WKY was also significantly bigger than in NWR. The same differences were found regarding the mean arterial blood pressure. The mean arterial blood pressure was significantly correlated with the logarithmic values of both the absolute and the relative CBV in SHR, WKY and NWR. These findings were compared with the results of other hypertensive rat models. It can be concluded that in hypertensive rats the CBV is likely to be dependent on the strain studied and independent of the blood pressure level or the expression of intraglomic vascular alterations.
在16 - 18周龄时，比较了雄性自发性高血压大鼠（SHR）、Wistar Kyoto大鼠（WKY）和随机繁殖的正常血压Wistar大鼠（NWR）的颈动脉体体积。SHR的颈动脉体绝对体积和相对体积（CBV）均显著大于WKY或NWR。此外，WKY的绝对和相对CBV也显著大于NWR。平均动脉血压也存在同样的差异。SHR、WKY和NWR的平均动脉血压与绝对和相对CBV的对数值均显著相关。将这些结果与其他高血压大鼠模型的结果进行了比较。可以得出结论，在高血压大鼠中，CBV可能取决于所研究的品系，而与血压水平或球内血管改变的表达无关。
