Hohai University, Nanjing, 210098, China.
Core Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China.
BMC Public Health. 2021 Sep 16;21(1):1692. doi: 10.1186/s12889-021-11726-4.
The objective of this study was to detect the urinary levels of dimethoate, benzo(a) pyrene (BaP), and bisphenol A (BPA) in first-year Hohai University students with different geographic origins.
First-morning urine samples were collected from 540 healthy freshmen aged 17 to 19 years. Chemical levels were measured using β-glucuronidase hydrolysis followed by a high-performance liquid chromatography-tandem mass spectrometry-based method. Geometric means (GMs) of these three chemicals are presented by body mass index (BMI) and location in a volume-based and creatinine-standardized way.
GM concentrations of omethoate, BPA and 3-OHBaP were 9.47 μg/L (10.80 μg/g creatinine), 3.54 μg/L (4.04 μg/g creatinine) and 0.34 ng/L (0.39 ng/g creatinine), respectively. The GM concentration of omethoate in males was significantly higher than that in females. The individuals with a BMI higher than 23.9 had higher GM concentrations of omethoate, BPA, and 3-OHBaP. The inhabitants of Southwest China had significantly lower GM concentrations of omethoate, BPA, and 3-OHBaP than those who lived in other locations in China.
The average level of environmental chemical accumulation in freshmen is lower in Southwest China and differs in youth who live in different regions. In addition, obesity is correlated with higher toxin levels in youth.
本研究旨在检测来自不同地区的河海大学一年级学生尿液中的乐果、苯并（a）芘（BaP）和双酚 A（BPA）水平。
采集了 540 名 17 至 19 岁的健康大一新生的晨尿样本。使用β-葡萄糖醛酸酶水解法，结合高效液相色谱-串联质谱法进行化学水平测量。采用基于体重指数（BMI）和体积的肌酐标准化方法，以几何平均值（GM）表示这三种化学物质的水平。
乐果、BPA 和 3-OHBaP 的 GM 浓度分别为 9.47μg/L（10.80μg/g 肌酐）、3.54μg/L（4.04μg/g 肌酐）和 0.34ng/L（0.39ng/g 肌酐）。男性乐果 GM 浓度明显高于女性。BMI 高于 23.9 的个体乐果、BPA 和 3-OHBaP 的 GM 浓度较高。与其他地区相比，中国西南地区的个体乐果、BPA 和 3-OHBaP 的 GM 浓度明显较低。
西南地区新生环境化学物质积累的平均水平较低，不同地区的年轻人也存在差异。此外，肥胖与年轻人的毒素水平升高有关。
