Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, 519000, Guangdong, PR China; The Biomedical Translational Research Institute, Jinan University Faculty of Medical Science, Jinan University, Guangzhou, 510632, PR China.
Radiotherapy Department of Nasopharyngeal Carcinoma, Cancer Center, First People's Hospital of Foshan Affiliated to Sun Yat-sen University, Foshan, 528000, PR China.
Chemosphere. 2020 May;247:125987. doi: 10.1016/j.chemosphere.2020.125987. Epub 2020 Jan 21.
Bisphenol analogs (BPs), as the industrial chemicals, are widely used in consumer products. Limited information exists regarding human exposure to BPs in university students in China. In this study, we detected concentrations of seven BPs, namely bisphenol A (BPA), bisphenol AF (BPAF), bisphenol P (BPP), bisphenol AP (BPAP), bisphenol Z (BPZ), bisphenol S (BPS), and bisphenol F (BPF), in paired urine (n = 160) and indoor dust samples (n = 40) from university students in South China. High detection rates and levels (median) was found in BPA in paired urine (99%, 3.57 ng/mL) and indoor dust (80%, 2.98 μg/g) samples, followed by BPS (88%, 0.24 ng/mL; 78%, 0.22 μg/g). These findings suggest that BPA remains the major BPs used in consumer products. A positive relationship between urinary ∑BPs (sum of six BPs) concentration and indoor dust was observed (r = 0.444, p < 0.01), indicated that exposure to non-dietary BPs may also be significant to human exposure. The median EDI values (ng/kg bw/day) of ∑BPs in males (119.6) were relatively higher than (p < 0.05) those in females (84.6). By contrast, the median EDI of BPs (except for BPAF) in dust form female dormitories were slightly higher than that in dust from male dormitories. Notably, BPF was the most ingested from indoor dust (dormitory dust). This study is the first time to document the occurrence of BPs in paired urine and indoor dust in university students from China.
双酚类化合物（BPs）作为工业化学品，广泛应用于消费品中。目前关于中国大学生体内 BPs 暴露水平的信息有限。在这项研究中，我们检测了华南地区大学生尿液（n=160）和室内灰尘样本（n=40）中七种 BPs 的浓度，分别是双酚 A（BPA）、双酚 AF（BPAF）、双酚 P（BPP）、双酚 AP（BPAP）、双酚 Z（BPZ）、双酚 S（BPS）和双酚 F（BPF）。尿液和室内灰尘样本中 BPA 的检出率和浓度（中位数）最高，分别为 99%（3.57ng/mL）和 80%（2.98μg/g），其次是 BPS（88%，0.24ng/mL；78%，0.22μg/g）。这些发现表明 BPA 仍然是消费品中主要使用的 BPs。尿液中∑BPs（六种 BPs 的总和）浓度与室内灰尘之间呈正相关（r=0.444，p<0.01），表明非饮食来源的 BPs 暴露也可能对人体暴露产生重要影响。男性尿液中∑BPs（119.6ng/kg bw/day）的 EDI 值中位数高于女性（p<0.05，84.6ng/kg bw/day）。相比之下，女性宿舍室内灰尘中 BPs（BPAF 除外）的 EDI 中位数略高于男性宿舍。值得注意的是，BPF 是从室内灰尘（宿舍灰尘）中摄入最多的 BPs。本研究首次报道了中国大学生尿液和室内灰尘中 BPs 的存在情况。
