Xu Lingyun, Zhu Hong, Gao Fei, Tang Yinghua, Zhu Yajun, Sun Zhiqiang, Wang Jian
Department of Breast Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213001, China.
Department of Radiation Oncology, Minhang Branch of Cancer Hospital of Fudan University, Shanghai 200240, China.
Gene. 2019;721S:100014. doi: 10.1016/j.gene.2019.100014. Epub 2019 Mar 25.
Breast cancer is the most common female malignancy and the major cause of cancer-related death in women. Long non-coding RNAs (lncRNAs), as oncogenic or tumor suppressor factor, involved in the development and progression of various cancers. In this study, we sought to investigate the function of lncRNA CBR3-AS1 in breast cancer. We evaluated the expression pattern of CBR3-AS1 in breast cancer tissues and cell lines, explored the correlation between CBR3-AS1 expression and the survival time of breast cancer patients, and probed the effect of CBR3-AS1 on tumor progression of breast cancer through loss-of-function and gain-of-function strategies. Our results showed that CBR3-AS1 was overexpressed in breast cancer tissues and cell lines and predicted the prognosis of breast cancer patients. And CBR3-AS1 exerted biological function as an oncogenic lncRNA, involved in the regulation of cell proliferation, colony formation, apoptosis and tumor growth in breast cancer. Taken together, CBR3-AS1 was up-regulated in breast cancer and promoted the risk of breast cancer. It may be a novel therapeutic target and potential prognostic marker for breast cancer.
乳腺癌是最常见的女性恶性肿瘤，也是女性癌症相关死亡的主要原因。长链非编码RNA（lncRNAs）作为致癌或肿瘤抑制因子，参与了各种癌症的发生和发展。在本研究中，我们旨在探讨lncRNA CBR3-AS1在乳腺癌中的功能。我们评估了CBR3-AS1在乳腺癌组织和细胞系中的表达模式，探讨了CBR3-AS1表达与乳腺癌患者生存时间之间的相关性，并通过功能丧失和功能获得策略探究了CBR3-AS1对乳腺癌肿瘤进展的影响。我们的结果表明，CBR3-AS1在乳腺癌组织和细胞系中过表达，并可预测乳腺癌患者的预后。并且CBR3-AS1作为一种致癌lncRNA发挥生物学功能，参与调节乳腺癌细胞的增殖、集落形成、凋亡和肿瘤生长。综上所述，CBR3-AS1在乳腺癌中上调并增加了乳腺癌风险。它可能是乳腺癌的一个新的治疗靶点和潜在的预后标志物。
