Drayna D, Fielding C, McLean J, Baer B, Castro G, Chen E, Comstock L, Henzel W, Kohr W, Rhee L
J Biol Chem. 1986 Dec 15;261(35):16535-9.
The amino acid sequence of human apolipoprotein D, a component of high density lipoprotein, has been obtained from the cloned cDNA sequence. The 169-amino acid protein has no marked similarity to other apolipoprotein sequences, but has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2u-globulin protein superfamily. Apolipoprotein D mRNA has been detected in human liver, intestine, pancreas, kidney, placenta, adrenal, spleen, and fetal brain tissue. Tissue culture cells transfected with the cloned cDNA secrete material that reacts with anti-apoD antibodies.
人类载脂蛋白D是高密度脂蛋白的一个组成部分，其氨基酸序列已从克隆的cDNA序列中获得。这种由169个氨基酸组成的蛋白质与其他载脂蛋白序列没有明显的相似性，但与血浆视黄醇结合蛋白及α2u球蛋白蛋白质超家族的其他成员具有高度同源性。已在人类肝脏、肠道、胰腺、肾脏、胎盘、肾上腺、脾脏和胎儿脑组织中检测到载脂蛋白D信使核糖核酸。用克隆的cDNA转染的组织培养细胞分泌能与抗载脂蛋白D抗体发生反应的物质。
