Israeli Defense Forces Medical Corps, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Israeli Defense Forces Medical Corps, Israel.
Vaccine. 2021 Oct 8;39(42):6210-6212. doi: 10.1016/j.vaccine.2021.07.096. Epub 2021 Aug 5.
Route of vaccine administration plays a role in extent and quality of immunogenicity. 790 military personnel accidentally received the first of two doses of Pfizer/BioNTech mRNA anti Covid-19 vaccine using a needle intended for subcutaneous administration. A serological blood test (on day 21, prior to the second intramuscular dose) was performed, analyzing whether immunological response was elicited. 98.2% demonstrated seroconversion. IgG titers were negatively correlated with age and did not correlate with BMI. Our results could help reassure providers confronted with a similar mistake and may even imply a possibly new and effective administration route.
疫苗接种途径在免疫原性的程度和质量方面发挥作用。790 名军事人员在无意中使用皮下注射用针头接种了两剂辉瑞/生物科技 mRNA 抗新冠病毒疫苗的第一剂。在（第二次肌肉注射前的第 21 天）进行了血清学血液检测，以分析是否引发了免疫反应。98.2%的人出现了血清转化。IgG 滴度与年龄呈负相关，与 BMI 无关。我们的结果可以帮助安抚遇到类似错误的医务人员，甚至可能暗示一种新的、有效的接种途径。
