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Fournier 坏疽:我们的五年系列研究和真空辅助闭合治疗的作用。

Fournier's Gangrene: Our Five-Year Series and the Role of Vacuum-Assisted Closure in the Treatment.

机构信息

Department of Surgical Oncology, Cukurova University, Balcalı Training and Research Hospital, Adana, Turkey.

Department of General Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

出版信息

Niger J Clin Pract. 2021 Sep;24(9):1277-1282. doi: 10.4103/njcp.njcp_387_20.

Abstract

BACKGROUND

Fournier's Gangrene (FG) is the necrotizing fasciitis of the perineal region.

AIMS

To compare the effectiveness of debridement alone and debridement with vacuum-assisted closure in the treatment of Fournier's gangrene.

METHODS

Twenty-two patients operated for FG were analyzed retrospectively. Debridement-only and debridement + VAC treatment groups were compared in terms of age, gender, predisposing factors, comorbid diseases, intensive care unit and hospital stay durations, laboratory results, septic shock, treatment methods, Fournier' gangrene severity index (FGSI) and mortality.

RESULTS

The M/F ratio was 13/9. There were 10 and 12 patients in debridement-only and debridement + VAC groups, respectively. Ten patients (45.5%) were admitted to intensive care unit, 8 (36.4%) needed colostomy and 7 (31.9%) developed septic shock, respectively. The mortality rate was 27.3%. There was no significant difference in terms of age, gender, laboratory parameters, number of debridement, length of stay in intensive care unit and hospital, shock duration, and mortality (P > 0.05). The FGSI scores also did not show any difference between the groups which showed that the severity of the disease in both groups are similar.

CONCLUSION

The VAC treatment was found not to provide a statistically significant benefit on mortality. Early and adequate debridement and antibiotic are still the most important factors in the treatment of FG and to reduce mortality.

摘要

背景

Fournier 坏疽(FG)是会阴部的坏死性筋膜炎。

目的

比较单纯清创术和清创术联合负压创面治疗技术(VAC)治疗 Fournier 坏疽的疗效。

方法

回顾性分析 22 例行 FG 手术的患者。比较单纯清创术组和清创术+VAC 治疗组的年龄、性别、易患因素、合并症、重症监护病房和住院时间、实验室结果、感染性休克、治疗方法、Fournier 坏疽严重指数(FGSI)和死亡率。

结果

男女比例为 13/9。单纯清创术组和清创术+VAC 治疗组分别有 10 例和 12 例患者。10 例(45.5%)患者入住重症监护病房,8 例(36.4%)患者需要结肠造口术,7 例(31.9%)患者发生感染性休克。死亡率为 27.3%。两组在年龄、性别、实验室参数、清创次数、重症监护病房和住院时间、休克持续时间和死亡率方面无显著差异(P>0.05)。两组的 FGSI 评分也无差异,表明两组疾病的严重程度相似。

结论

VAC 治疗并未显著降低死亡率。早期充分清创和使用抗生素仍然是治疗 FG 和降低死亡率的最重要因素。

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