Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, United States.
Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States.
Nat Commun. 2021 Sep 16;12(1):5473. doi: 10.1038/s41467-021-25383-z.
Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.
植入物相关感染是关节置换术失败的最常见原因，需要进行翻修手术和更换新的植入物，每年造成的成本高达 86 亿美元。为了解决这个问题，我们开发了一类涂层技术，可在手术室中应用，整个过程不到 10 分钟，并且可以结合任何所需的抗生素。我们的涂层技术使用支化聚乙二醇（PEG）和聚烯丙基硫醇（PAM）聚合物的原位偶联反应来生成两亲性聚合物涂层。我们在术后感染和脊柱手术后感染的小鼠模型中证明了该涂层在预防植入物感染方面的体内功效。我们的技术在有或没有全身抗生素（即标准护理）的情况下均显示出疗效。我们的涂层技术可在临床相关的时间范围内应用，不需要修改植入物的制造工艺，也不会改变植入物的保质期。
