Lv Jie, Wang Ning, Zhu Yongsheng, Luo Qian, Li Yongxian, Li Jian
Department of Urology, Luzhou People's Hospital, Luzhou, China.
Department of Urology, Affiliated Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.
Transl Androl Urol. 2021 Aug;10(8):3465-3475. doi: 10.21037/tau-21-563.
Holmium lasers have been used to treat bladder stones and achieve good therapeutic effects, but its efficacy remains to be explored.
The PubMed, Embase, Medline, Ovid, Springer, and Web of Sciences databases were searched from their establishment to December 31, 2020. Studies of randomized control trials (RCTs) examining the treatment of vesical calculi by holmium laser lithotripsy were identified. The Cochrane Handbook for Systematic Reviews of Intervention 5.0.2 was used to assess risk bias, and Rev Man5.3 was used to conduct the meta-analysis.
A total of 10 studies, comprising 1,642 subjects, were included. The meta-analysis results showed that the surgery time and the hospitalization time of patients treated with holmium laser lithotripsy decreased, and the calculus removal rate increased. The experimental group had a lower incidence of adverse reactions, such as postoperative urinary tract infection, mucosal damage, vesical perforation, residual calculi, hematuria, and abdominal pain than the control group; however, no notable difference was observed in relation to surgery time, hospital stay, the calculus removal rate, mucosal damage, bladder perforation, hematuria, and abdominal pain between the 2 groups.
Holmium laser lithotripsy significantly reduced the hospitalization time of patients treated with holmium laser lithotripsy and elevated the removal rate.
钬激光已被用于治疗膀胱结石并取得了良好的治疗效果，但其疗效仍有待探索。
检索了PubMed、Embase、Medline、Ovid、Springer和Web of Sciences数据库，检索时间从各数据库建立至2020年12月31日。纳入了通过钬激光碎石术治疗膀胱结石的随机对照试验（RCT）研究。采用Cochrane干预系统评价手册5.0.2评估风险偏倚，并使用Rev Man5.3进行荟萃分析。
共纳入10项研究，涉及1642名受试者。荟萃分析结果显示，接受钬激光碎石术治疗的患者手术时间和住院时间缩短，结石清除率提高。试验组术后尿路感染、黏膜损伤、膀胱穿孔、残留结石、血尿和腹痛等不良反应的发生率低于对照组；然而，两组在手术时间、住院时间、结石清除率、黏膜损伤、膀胱穿孔、血尿和腹痛方面未观察到显著差异。
钬激光碎石术显著缩短了接受钬激光碎石术治疗患者的住院时间，并提高了清除率。
