Akesson B, Steen B
Department of Clinical Chemistry, University Hospital, Lund, Sweden.
Compr Gerontol A. 1987 Jun;1(2):61-4.
Plasma selenium and plasma glutathione peroxidase were measured in 483 68-year-old men participating in a longitudinal population study, in which the probands were representatively selected. The prevalence of cancer and coronary heart disease was assessed by a structured interview. In plasma the concentration of selenium was 1.08 +/- 0.18 mumol X l-1 and the activity of glutathione peroxidase 540 +/- 90 mumol X l-1 X min-1. Plasma selenium was correlated to glutathione peroxidase activity (r = 0.49, p less than 0.001), but not significantly to plasma albumin levels (r = 0.18). Plasma selenium and glutathione peroxidase values in subjects with cancer or angina pectoris were not significantly different from those in subjects without these diseases. Plasma selenium concentration and glutathione peroxidase activity in the subjects who died within 1 year of screening were 89% and 88%, respectively, of the values among survivors (p less than 0.01). For the subjects who died during the second year after screening, these variables did not differ significantly from the values among survivors, 97% and 99%, respectively. Since the relation of low selenium and glutathione peroxidase to mortality was observed only for the first year, it was probably due to a disturbed nutritional state prior to death, rather than to a long-term negative influence of low plasma selenium on the mortality risk. Furthermore, the data have failed to demonstrate a relationship between selenium status and cancer or angina pectoris.
在一项纵向人群研究中，对483名68岁男性进行了血浆硒和血浆谷胱甘肽过氧化物酶的测量，这些研究对象是经过代表性抽样选取的。通过结构化访谈评估癌症和冠心病的患病率。血浆中硒的浓度为1.08±0.18μmol·L⁻¹，谷胱甘肽过氧化物酶的活性为540±90μmol·L⁻¹·min⁻¹。血浆硒与谷胱甘肽过氧化物酶活性相关（r = 0.49，p<0.001），但与血浆白蛋白水平无显著相关性（r = 0.18）。患有癌症或心绞痛的受试者的血浆硒和谷胱甘肽过氧化物酶值与未患这些疾病的受试者无显著差异。在筛查后1年内死亡的受试者的血浆硒浓度和谷胱甘肽过氧化物酶活性分别为幸存者的89%和88%（p<0.01）。对于在筛查后第二年死亡的受试者，这些变量与幸存者的值无显著差异，分别为97%和99%。由于仅在第一年观察到低硒和谷胱甘肽过氧化物酶与死亡率之间的关系，这可能是由于死亡前营养状态紊乱，而不是低血浆硒对死亡风险的长期负面影响。此外，数据未能证明硒状态与癌症或心绞痛之间的关系。
