Wasowicz W, Gromadzińska J, Skłodowska M, Popadiuk S
Zakład Biochemii, Instytutu Nauk Podstawowych Wojskowej Akademii Medycznej, Gdansk, Poland.
J Trace Elem Electrolytes Health Dis. 1994 Mar;8(1):53-7.
In this work we studied 205 children with cancer, aged 6 months to 7 years, who had been diagnosed as suffering from various types of neoplasm. In blood of these children we determined the selenium concentration and glutathione peroxidase activity by fluorometric and spectrophometric methods, respectively. The control group consisted of 128 healthy children. In all groups of children with cancer we observed a significantly lower selenium concentration and lowered glutathione peroxidase activity. We found statistical differences in selenium concentration between first or second and third, and between first and fourth or fifth stages of the disease, only in 3-7 year-old patients. Glutathione peroxidase activity was statistically depressed in the same age group between the first or second and third stages of the disease. Generally, there were no differences in the concentration of the microelement or in the glutathione peroxidase activity between children before and during treatment with cytostatics.
在这项研究中，我们对205名年龄在6个月至7岁之间、被诊断患有各种类型肿瘤的癌症患儿进行了研究。我们分别采用荧光法和分光光度法测定了这些患儿血液中的硒浓度和谷胱甘肽过氧化物酶活性。对照组由128名健康儿童组成。在所有癌症患儿组中，我们观察到硒浓度显著降低，谷胱甘肽过氧化物酶活性也降低。仅在3至7岁的患者中，我们发现疾病第一或第二阶段与第三阶段之间以及第一阶段与第四或第五阶段之间的硒浓度存在统计学差异。在同一年龄组中，疾病第一或第二阶段与第三阶段之间的谷胱甘肽过氧化物酶活性在统计学上受到抑制。一般来说，在使用细胞抑制剂治疗之前和治疗期间，儿童体内微量元素的浓度或谷胱甘肽过氧化物酶活性没有差异。
