Department of Nuclear Medicine, Xin Hua Hospital Affiliated To Shanghai Jiao Tong University School, 1665 Kongjiang Road, Shanghai 200092, China.
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Nanoscale. 2021 Sep 17;13(35):15021-15030. doi: 10.1039/d1nr02892h.
Anaplastic thyroid carcinoma (ATC), as one of the most aggressive human malignancies, cannot be cured by iodine (I) internal radiotherapy (RT) because the tumor cells cannot effectively take up I and are resistant to radiotherapy. In this study, a facile and simple method was proposed to synthesize mesoporous polydopamine nanoparticles (MPDA) and tailor their morphologies by component-adjusting Pluronic micelle-guided polymerization. Then, MPDA were used not only as nanocarriers to radiolabel I, but also as photothermal conversion agents for photothermal therapy (PTT) to promote RT. The iodine-labeling capacity and photothermal conversion efficiency of MPDA can be enhanced by optimizing their morphologies. It was found that MPDA NPs with a cerebroid pore channel structure (CPDA) showed the highest iodine-carrying capacity and a higher photothermal conversion efficiency as a result of their maximum specific surface area and unique morphology. In subsequent experiments and , our ATC animal models showed impressive therapeutic responses to CPDA-I NPs because of the synergistic effect of PTT and RT. Additionally, CPDA-I NPs can be utilized to obtain high-quality SPETC/CT images of tumors, which can guide clinical therapy for ATC. Considering their great biosafety, these radioiodine-labeled CPDA NPs may serve as a promising tool in combined therapy and diagnosis in ATC.
间变性甲状腺癌（ATC）是最具侵袭性的人类恶性肿瘤之一，由于肿瘤细胞不能有效摄取碘（I）且对放射治疗有抗性，因此不能通过碘内放射疗法（RT）治愈。在这项研究中，提出了一种简便的方法来合成介孔聚多巴胺纳米粒子（MPDA），并通过调节 Pluronic 胶束导向聚合来调整其形态。然后，MPDA 不仅可以作为放射性碘标记的纳米载体，还可以作为光热治疗（PTT）的光热转换剂来促进 RT。通过优化其形态，可以增强 MPDA 的碘标记能力和光热转换效率。研究发现，具有脑状孔道结构的 MPDA NPs（CPDA）具有最高的载碘能力和更高的光热转换效率，这是由于其具有最大的比表面积和独特的形态。在随后的实验和 中，我们的 ATC 动物模型对 CPDA-I NPs 表现出了令人印象深刻的治疗反应，这是由于 PTT 和 RT 的协同作用。此外，CPDA-I NPs 可用于获得肿瘤的高质量 SPETC/CT 图像，从而指导 ATC 的临床治疗。考虑到其良好的生物安全性，这些放射性碘标记的 CPDA NPs 可能成为 ATC 联合治疗和诊断的有前途的工具。
