Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-Cho, Chuou-Ku, Kobe, Hyogo 650-0017, Japan.
J Mater Chem B. 2021 Oct 13;9(39):8348-8354. doi: 10.1039/d1tb00919b.
Close attachment of soft tissues onto implantable devices inside the body is regarded as an optimal condition for preventing complications (, infections and abscess formation around implants, and the migration of small injectable devices). We have recently reported that an α-type commercially pure Ti (CpTi) film after a long-term acid treatment and air drying showed a remarkable soft tissue adhesiveness immediately (, within a few seconds) after the attachment onto soft tissues. Herein, we conducted acid treatment for (α + β)-type Ti-6Al-4V alloys and compared their mechanical properties and the immediate soft-tissue adhesiveness with α-type CpTi. The acid treatment for Ti-6Al-4V also promoted immediate soft-tissue adhesion, although the treatment was less effective than for CpTi. The tensile strength of acid-treated Ti-6Al-4V was much higher than that of acid-treated CpTi or human skin tissues, although the degree of hydrogen embrittlement was more severe than that for CpTi. These results suggest that the small amount of Al in the major α phase and/or the minor β phase of Ti-6Al-4V has a significant influence not only on the mechanical properties but also on the immediate soft-tissue adhesiveness of Ti-based solid-state adhesives after the acid treatment.
将软组织紧密附着在体内可植入设备上被认为是预防并发症（感染和植入物周围脓肿形成，以及小型可注射设备迁移）的最佳条件。我们最近报道，经过长期酸处理和空气干燥后的 α 型纯钛（CpTi）薄膜在附着到软组织后立即（几秒钟内）表现出显著的软组织粘附性。在此，我们对（α+β）-Ti-6Al-4V 合金进行了酸处理，并比较了它们的机械性能和与 α 型 CpTi 的即刻软组织粘附性。Ti-6Al-4V 的酸处理也促进了即刻软组织附着，尽管其效果不如 CpTi 那么显著。尽管氢脆程度比 CpTi 更严重，但经过酸处理的 Ti-6Al-4V 的拉伸强度远高于经过酸处理的 CpTi 或人体皮肤组织。这些结果表明，Ti-6Al-4V 中的主要α相和/或少量β相中少量的 Al 不仅对机械性能，而且对酸处理后的基于 Ti 的固态胶粘剂的即刻软组织粘附性有重大影响。
