Chen Yanbo, Zhou Sani, Zhang Aiyuan, Huang Jing, Zhang Guangfang, Cui Lianqun
Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Department of Cardioangiology, Weifang People's Hospital, Weifang, 261041, Shandong, China.
Heart Vessels. 2022 Mar;37(3):419-425. doi: 10.1007/s00380-021-01935-7. Epub 2021 Sep 17.
Plasma ghrelin levels can be elevated in patients with acute heart failure (AHF). This study aimed to analyze the temporal changes and prognostic value of ghrelin levels in patients with AHF.
This prospective study included patients with AHF at the Cardiology Department, Weifang People's Hospital (May 2018-October 2019), and age- and sex-matched healthy controls. Plasma ghrelin levels were measured. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were used to evaluate whether ghrelin levels could predict major cardiac adverse events (MACEs) during a 1-year follow-up.
Finally, 92 patients with AHF and 50 healthy controls were enrolled. Ghrelin levels were higher in patients with AHF at 1, 3, 12, and 24 h compared with controls (all P < 0.01). Ghrelin levels in the AHF group were higher at 3 and 12 h than at 1 and 24 h (P < 0.001). Ghrelin level at 3 h in patients with AHF was negatively correlated with the left ventricular end-diastolic diameter and left ventricular ejection fraction (both P < 0.05). MACEs occurred in 48 patients with AHF. Ghrelin levels were higher in the MACE group than in the non-MACE group at 1 (P = 0.011) and 3 h (P = 0.034). Multivariable regression showed that ghrelin level at 3 h was independently associated with MACEs [OR = 0.629, 95% confidence interval (CI): 0.515-0.742, P = 0.010], but the area under the ROC curve was only 0.629 (95% CI 0.515-0.742).
Plasma ghrelin levels are elevated in AHF and patients with MACEs during follow-up.
急性心力衰竭（AHF）患者的血浆胃饥饿素水平可能会升高。本研究旨在分析AHF患者胃饥饿素水平的时间变化及其预后价值。
这项前瞻性研究纳入了潍坊市人民医院心内科的AHF患者（2018年5月至2019年10月）以及年龄和性别匹配的健康对照者。检测血浆胃饥饿素水平。采用多变量逻辑回归和受试者工作特征（ROC）曲线分析来评估胃饥饿素水平是否能够预测1年随访期间的主要心脏不良事件（MACE）。
最终，纳入了92例AHF患者和50例健康对照者。与对照组相比，AHF患者在1、3、12和24小时时的胃饥饿素水平更高（所有P<0.01）。AHF组在3小时和12小时时的胃饥饿素水平高于1小时和24小时时（P<0.001）。AHF患者3小时时的胃饥饿素水平与左心室舒张末期内径和左心室射血分数呈负相关（均P<0.05）。48例AHF患者发生了MACE。MACE组在1小时（P=0.011）和3小时（P=0.034）时的胃饥饿素水平高于非MACE组。多变量回归显示，3小时时的胃饥饿素水平与MACE独立相关[比值比（OR）=0.629，95%置信区间（CI）：0.515-0.742，P=0.010]，但ROC曲线下面积仅为0.629（95%CI 0.515-0.742）。
AHF患者以及随访期间发生MACE的患者血浆胃饥饿素水平升高。
