Takeshita H, Shimizu K, Hazama H
Department of Neuropsychiatry, Tottori University School of Medicine, Yonago, Japan.
Jpn J Psychiatry Neurol. 1987 Dec;41(4):733-41. doi: 10.1111/j.1440-1819.1987.tb00432.x.
The effects of neonatal treatment with estrogen or androgen on the development of cytosol estradiol (E2) receptors were examined in the rat pituitary, hypothalamus and amygdala. The treatment with estradiol benzoate (EB, 100 micrograms) significantly reduced the E2 receptor content in all of these regions in both sexes. But the treatment with testosterone propionate (TP, 1 mg) to the female rats significantly decreased the E2 receptor content in the pituitary and hypothalamus but not in the amygdala. The TP treatment to the male rats decreased the E2 receptor content in the hypothalamus and amygdala but not in the pituitary. The decreased cytosol E2 receptors in the hypothalamus and amygdala seem to be implicated in preventing the normal sexual development.
研究了新生大鼠经雌激素或雄激素处理后，其垂体、下丘脑和杏仁核中胞质雌二醇（E2）受体的发育情况。用苯甲酸雌二醇（EB，100微克）处理显著降低了两性所有这些区域的E2受体含量。但对雌性大鼠用丙酸睾酮（TP，1毫克）处理，显著降低了垂体和下丘脑的E2受体含量，而杏仁核中的未降低。对雄性大鼠用TP处理，降低了下丘脑和杏仁核的E2受体含量，但垂体中的未降低。下丘脑和杏仁核中胞质E2受体的减少似乎与阻止正常性发育有关。
