Department of Biology, College of Sciences, Jazan University, P.O. Box 2079, Jazan, 45142, Saudi Arabia.
Biology Department, College of Science, Imam Muhammad bin Saud Islamic University, B.o.box 90950, Riyadh, 11623, Saudi Arabia.
Environ Res. 2022 Mar;204(Pt B):112031. doi: 10.1016/j.envres.2021.112031. Epub 2021 Sep 14.
In the present investigation, the effect of mercuric chloride on gestation and lactation periods in mice was studied. The animals were treated with 10 ppm of HgCl and its complications were evaluated by supplementing 150 and 300 ppm of curcumin, respectively. Results indicated that HgCl increased depression-like behavior in treated animals compared to control and effects of depression in offspring significantly (p˂0.001) enhanced. Interestingly, the Tail suspension test clearly confirmed that the administration of curcumin enhanced the immobility (p˂0.001). The results confirmed that the curcumin administered mice spent less time in the closed arm (P < 0.001), whereas spent a very long time (P < 0.001) in the open arm. Related to the locomotor behaviors, number of squares crossed, wall rear, rear, and locomotion duration were decreased significantly (P < 0.001) while immobility duration was increased (P < 0.001) significantly compared to control. The anxiety and depression behaviors disorder due to mercuric chloride exposure indicated its availability via placenta or/and milk during lactation. The treatment with curcumin improved anxiety and depression behaviors compared to Hg experimental group.
在本研究中，研究了氯化汞对小鼠妊娠和哺乳期的影响。用 10 ppm 的 HgCl 处理动物，并分别补充 150 和 300 ppm 的姜黄素，评估其并发症。结果表明，与对照组相比，HgCl 增加了处理动物的抑郁样行为，且后代的抑郁作用显著增强（p<0.001）。有趣的是，悬尾试验清楚地证实，姜黄素的给药增强了不动性（p<0.001）。结果证实，给予姜黄素的小鼠在封闭臂上花费的时间更少（P<0.001），而在开放臂上花费的时间很长（P<0.001）。与运动行为相关的是，穿越的方格数、壁后、后肢和运动时间显著减少（P<0.001），而不动时间显著增加（P<0.001）与对照组相比。由于氯化汞暴露导致的焦虑和抑郁行为障碍表明其在胎盘或/和哺乳期通过胎盘或/和乳汁传递。与 Hg 实验组相比，姜黄素的治疗改善了焦虑和抑郁行为。
