Program for Pregnancy and Postpartum Health, Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Program for Pregnancy and Postpartum Health, Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Can J Cardiol. 2021 Dec;37(12):2014-2025. doi: 10.1016/j.cjca.2021.09.003. Epub 2021 Sep 14.
Of all physiological systems, the cardiovascular system takes on the most profound adaptation in pregnancy to support fetal growth and development. The adaptations that arise are systemic and involve structural and functional changes that can be observed at the cerebral, central, peripheral, and microvascular beds. This includes, although is not limited to, increased heart rate, stroke volume, and cardiac output with negligible change to blood pressure, reductions in vascular resistance, and cerebral blood flow velocity, systemic artery enlargement, and enhanced endothelial function. All of this takes place to accommodate blood volume expansion and ensure adequate fetal and maternal oxygen delivery. In some instances, the demand placed on the vasculature can manifest as cardiovascular maladaptation and thus, cardiovascular complications can arise. Exercise is recommended in pregnancy because of its powerful ability to reduce the incidence and severity of cardiovascular complications in pregnancy. However, the mechanism by which it acts is poorly understood. The first of our aims in this review was to describe the systemic adaptations that take place in pregnancy. Our second aim was to describe the influence of exercise on these systemic adaptations. It is anticipated that this review can comprehensively capture the extent of knowledge in this area while identifying areas that warrant further investigation.
在所有生理系统中,心血管系统在妊娠期间发生的适应性变化最大,以支持胎儿的生长和发育。这些适应性变化是全身性的,涉及到可以在大脑、中枢、外周和微血管床观察到的结构和功能变化。这包括但不限于心率、每搏输出量和心输出量的增加,而血压几乎没有变化,血管阻力和脑血流速度降低,体动脉增大和内皮功能增强。所有这些都是为了适应血容量的增加,确保胎儿和母体的氧气供应充足。在某些情况下,血管系统的需求可能表现为心血管适应性不良,从而导致心血管并发症的发生。由于运动具有降低妊娠中心血管并发症发生率和严重程度的强大能力,因此建议在妊娠期间进行运动。然而,其作用机制尚不清楚。我们综述的第一个目的是描述妊娠期间发生的全身性适应性变化。我们的第二个目的是描述运动对这些系统性适应的影响。我们希望本综述能够全面地捕捉这一领域的知识程度,同时确定需要进一步研究的领域。