MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, OX3 9DS, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute, Nuffield Department of Medicine, Oxford University, Oxford, OX3 7BN, UK.
MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, OX3 9DS, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute, Nuffield Department of Medicine, Oxford University, Oxford, OX3 7BN, UK.
Curr Opin Virol. 2021 Oct;50:183-191. doi: 10.1016/j.coviro.2021.08.009. Epub 2021 Sep 8.
Immunodominance is a complex and highly debated topic of T cell biology. The current SARS-CoV-2 pandemic has provided the opportunity to profile adaptive immune responses and determine molecular factors contributing to emerging responses towards immunodominant viral epitopes. Here, we discuss parameters that alter the dynamics of CD8 viral epitope processing, generation and T-cell responses, and how immunodominance counteracts viral immune escape mechanisms that develop in the context of emerging SARS-CoV-2 variants.
免疫优势是 T 细胞生物学中一个复杂且备受争议的话题。当前的 SARS-CoV-2 大流行提供了一个机会，可以分析适应性免疫反应，并确定导致针对免疫优势病毒表位的新兴反应的分子因素。在这里，我们讨论了改变 CD8 病毒表位加工、产生和 T 细胞反应动态的参数，以及免疫优势如何对抗在新兴 SARS-CoV-2 变体背景下发展的病毒免疫逃逸机制。
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