Biostatistics Center, Massachusetts General Hospital, 50 Staniford Street, Suite 560, Boston, MA, 02114, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, 550 16th Street, 2(nd)Floor, San Francisco, CA, 94158, USA.
Olga Tennison Autism Research Centre, School of Psychology and Public Health, La Trobe University, Kingsbury Drive, Bundoora, VIC, 3086, Australia.
Sleep Med. 2021 Nov;87:69-76. doi: 10.1016/j.sleep.2021.08.022. Epub 2021 Aug 31.
Sleep problems are common in autistic children and adversely impact daytime functioning. The Children's Sleep Habits Questionnaire (CSHQ) [39] was developed from a community-based sample of children and has validated a cut-off score of 41. Katz et al. [50] developed an abbreviated 23-item four-factor version of the CSHQ, which may be useful when assessing sleep in autistic children. However, a cut-off value has not yet been developed.
Our objective was to develop and validate a cut-off for the CSHQ-autism total score in order to identify sleep problems among autistic children. We hypothesized that the derived cut-off value for the CSHQ-autism would perform better than the original CSHQ cut at 41 on validation in a sample of autistic children.
Age-specific cut-off values were developed and validated using receiver operating characteristic analysis.
The derived cut-off values for the CSHQ-autism total score were 34, 35, 33, and 35 for the 2-3, 4-10, 11-17, and 2-17 years age groups, respectively. On validation, all cut-off values performed with moderate to high sensitivity (76.6-82.4%) and moderate specificity (69.1-75.5%), while the original CSHQ cut at 41 had high sensitivity (89.9-93.0%) but low specificity (42.6-57.7%). Using McNemar's tests, the CSHQ-autism had significantly higher specificity but lower sensitivity than the original CSHQ cut at 41 in all age groups.
The CSHQ-autism cut-off values performed better overall than the original CSHQ cut at 41 in a sample of autistic children. The CSHQ-autism cut-off can help identify sleep problems among autistic children.
睡眠问题在自闭症儿童中很常见,会对日间功能产生不良影响。《儿童睡眠习惯问卷》(CSHQ)[39]是从基于社区的儿童样本中发展而来的,其设定的 41 分为临界值。Katz 等人[50]开发了 CSHQ 的一个简化的 23 项四分制版本,在评估自闭症儿童的睡眠时可能很有用。但是,目前尚未设定临界值。
我们的目的是为 CSHQ-自闭症总分制定并验证一个临界值,以确定自闭症儿童的睡眠问题。我们假设,在自闭症儿童样本中验证时,与原始 CSHQ 的 41 分临界值相比,得出的 CSHQ-自闭症临界值表现会更好。
使用受试者工作特征曲线分析制定和验证年龄特异性临界值。
CSHQ-自闭症总分的临界值分别为 2-3、4-10、11-17 和 2-17 岁年龄组的 34、35、33 和 35。在验证时,所有临界值的灵敏度均为中等至高(76.6-82.4%),特异性为中等(69.1-75.5%),而原始 CSHQ 临界值为 41,灵敏度较高(89.9-93.0%),但特异性较低(42.6-57.7%)。使用 McNemar 检验,在所有年龄组中,CSHQ-自闭症的特异性均显著高于原始 CSHQ 临界值 41,而灵敏度则较低。
在自闭症儿童样本中,CSHQ-自闭症的临界值总体上优于原始 CSHQ 的 41 分临界值。CSHQ-自闭症的临界值可以帮助识别自闭症儿童的睡眠问题。