Khurana Pratishtha, Pulicharla Rama, Kaur Brar Satinder
Department of Civil Engineering, Lassonde School of Engineering, York University, North York, Toronto, Ontario M3J 1P3, Canada.
Department of Civil Engineering, Lassonde School of Engineering, York University, North York, Toronto, Ontario M3J 1P3, Canada.
Environ Int. 2021 Dec;157:106863. doi: 10.1016/j.envint.2021.106863. Epub 2021 Sep 14.
Unregulated usage, improper disposal, and leakage from pharmaceutical use and manufacturing sites have led to high detection levels of antibiotic residues in wastewater and surface water. The existing water treatment technologies are insufficient for removing trace antibiotics and these residual antibiotics tend to interact with co-existing metal ions and form antibiotic-metal complexes (AMCs) with altered bioactivity profile and physicochemical properties. Typically, antibiotics, including tetracyclines, fluoroquinolones, and sulphonamides, interact with heavy metals such as Fe, Co, Cu, Ni, to form AMCs which are more persistent and toxic than parent compounds. Although many studies have reported antibiotics detection, determination, distribution and risks associated with their environmental persistence, very few investigations are published on understanding the chemistry of these complexes in the wastewater and sludge matrix. This review, therefore, summarizes the structural features of both antibiotics and metals that facilitate complexation in wastewater. Further, this work critically appraises the treatment methods employed for antibiotic removal, individually and combined with metals, highlights the knowledge gaps, and delineates future perspectives for their treatment.
药物使用和生产场所的无节制使用、不当处置及泄漏导致废水和地表水中抗生素残留的高检测水平。现有的水处理技术不足以去除痕量抗生素，并且这些残留抗生素倾向于与共存的金属离子相互作用，形成具有改变的生物活性特征和物理化学性质的抗生素 - 金属络合物（AMCs）。通常，包括四环素、氟喹诺酮类和磺胺类在内的抗生素与铁、钴、铜、镍等重金属相互作用，形成比母体化合物更持久且毒性更大的AMCs。尽管许多研究报告了抗生素的检测、测定、分布及其环境持久性相关的风险，但关于理解废水和污泥基质中这些络合物的化学性质的研究却很少发表。因此，本综述总结了废水中促进络合作用的抗生素和金属的结构特征。此外，这项工作批判性地评估了单独以及与金属结合使用的抗生素去除处理方法，突出了知识空白，并阐述了其处理的未来前景。
