Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, South Tower #8310, Nashville, TN 37232, USA.
Otolaryngol Clin North Am. 2021 Dec;54(6):1093-1100. doi: 10.1016/j.otc.2021.07.004. Epub 2021 Sep 15.
Patients with auditory neuropathy (AN)/auditory synaptopathy (AS) present unique evaluation and management challenges. Communication ability using auditory stimuli varies among patients, with particular difficulty understanding speech in noise. Auditory physiologic responses are key to accurate identification and monitoring of patients with AN/AS. Management approaches should consider individual variation and the possibility of change over time. Many patients with accurately characterized AN/AS demonstrate success with cochlear implants. Areas of discovery, including understanding of synaptic and neural mechanisms, genotype/phenotype relationships, and use of cochlear and cortical evoked potentials, will promote accurate clinical evaluation and management of infants, children, and adults with AN/AS.
听神经病（AN）/听神经突触病（AS）患者的评估和管理极具挑战。患者对听觉刺激的交流能力存在差异，特别是在嘈杂环境中理解言语存在困难。听觉生理反应是准确识别和监测 AN/AS 患者的关键。管理方法应考虑个体差异和随时间变化的可能性。许多经准确诊断的 AN/AS 患者使用人工耳蜗植入取得了成功。包括突触和神经机制、基因型/表型关系以及耳蜗和皮质诱发电位的应用等领域的发现，将促进对 AN/AS 婴幼儿、儿童和成人的准确临床评估和管理。
