Audiology and Speech-Language Pathology Program, University of Ottawa, Ottawa, Ontario, Canada.
School of Communication Sciences and Disorders (SCSD), Dalhousie University, Halifax, NS, Canada.
PLoS One. 2024 May 29;19(5):e0304316. doi: 10.1371/journal.pone.0304316. eCollection 2024.
Current evidence supports the benefits of cochlear implants (CIs) in children with hearing loss, including those with auditory neuropathy spectrum disorder (ANSD). However, there is limited evidence regarding factors that hold predictive value for intervention outcomes.
This retrospective case-control study consisted of 66 children with CIs, including 22 with ANSD and 44 with sensorineural hearing loss (SNHL) matched on sex, age, age at CI activation, and the length of follow-up with CIs (1:2 ratio). The case and control groups were compared in the results of five open-set speech perception tests, and a Forward Linear Regression Model was used to identify factors that can predict the post-CI outcomes.
There was no significant difference in average scores between the two groups across five outcome measures, ranging from 88.40% to 95.65%. The correlation matrix revealed that younger ages at hearing aid fitting and CI activation positively influenced improvements in speech perception test scores. Furthermore, among the variables incorporated in the regression model, the duration of follow-up with CIs, age at CI activation, and the utilization of two CIs demonstrated prognostic significance for improved post-CI speech perception outcomes.
Children with ANSD can achieve similar open-set speech perception outcomes as children with SNHL. A longer CI follow-up, a lower age at CI activation, and the use of two CIs are predictive for optimal CI outcome.
目前的证据支持为听力损失儿童（包括听神经病谱系障碍 [ANSD] 儿童）植入人工耳蜗（CI）的益处。然而，关于具有预测干预效果的因素的证据有限。
这是一项回顾性病例对照研究，共纳入 66 名植入 CI 的儿童，包括 22 名 ANSD 儿童和 44 名感音神经性听力损失（SNHL）儿童，两组按性别、CI 激活年龄、CI 随访时间（1:2 比例）进行匹配。比较两组在五项开放式言语感知测试中的结果，并采用正向线性回归模型来识别可预测 CI 后结果的因素。
两组在五项测试结果中平均得分无显著差异，范围为 88.40%至 95.65%。相关矩阵显示，助听器适配和 CI 激活的年龄越小，言语感知测试得分的改善越明显。此外，在纳入回归模型的变量中，CI 随访时间、CI 激活年龄以及使用两个 CI 对 CI 后言语感知改善结果具有预后意义。
ANSD 儿童可获得与 SNHL 儿童相似的开放式言语感知结果。CI 随访时间更长、CI 激活年龄更小、使用两个 CI 是获得最佳 CI 效果的预测因素。
