Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Neurobiology and Ageing Programme, Life Sciences Institute, National University of Singapore, Singapore.
Neurosci Biobehav Rev. 2021 Dec;131:429-450. doi: 10.1016/j.neubiorev.2021.09.028. Epub 2021 Sep 16.
The relaxin-3/RXFP3 system is one of several neuropeptidergic systems putatively implicated in regulating the behavioural alterations that characterise clinical depression and anxiety, making it a potential target for clinical translation. Accordingly, this systematic review identified published reports on the role of relaxin-3/RXFP3 signalling in these neuropsychiatric disorders and their behavioural endophenotypes, evaluating evidence from animal and human studies to ascertain any relationship. We searched PubMed, EMBASE, PsycINFO and Google Scholar databases up to February 2021, finding 609 relevant records. After stringent screening, 51 of these studies were included in the final synthesis. There was considerable heterogeneity in study designs and some inconsistency across study outcomes. However, experimental evidence is consistent with an ability of relaxin-3/RXFP3 signalling to promote arousal and suppress depressive- and anxiety-like behaviour. Moreover, meta-analyses of six to eight articles investigating food intake revealed that acute RXFP3 activation had strong orexigenic effects in rats. This appraisal also identified the lack of high-quality clinical studies pertinent to the relaxin-3/RXFP3 system, a gap that future research should attempt to bridge.
松弛素-3/RXFP3 系统是几种假定参与调节临床抑郁症和焦虑症特征的行为改变的神经肽系统之一，使其成为临床转化的潜在靶点。因此，本系统评价确定了关于松弛素-3/RXFP3 信号在这些神经精神疾病及其行为表型中的作用的已发表报告，评估了来自动物和人类研究的证据，以确定任何关系。我们搜索了 PubMed、EMBASE、PsycINFO 和 Google Scholar 数据库，截至 2021 年 2 月，发现了 609 条相关记录。经过严格筛选，这些研究中有 51 项被纳入最终综合分析。研究设计存在很大的异质性，研究结果也存在一些不一致。然而，实验证据表明松弛素-3/RXFP3 信号能够促进觉醒并抑制抑郁和焦虑样行为。此外，对六到八项研究食物摄入的荟萃分析表明，急性 RXFP3 激活在大鼠中具有强烈的食欲刺激作用。这项评估还发现缺乏与松弛素-3/RXFP3 系统相关的高质量临床研究，未来的研究应该试图弥补这一空白。
