College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, PR China.
School of Light Industry, Beijing Technology and Business University, Beijing 100048, PR China.
Curr Opin Pharmacol. 2021 Dec;61:1-5. doi: 10.1016/j.coph.2021.08.012. Epub 2021 Sep 17.
Obesity is a global epidemic that affects the lives and health of millions of people. The prevention and treatment of obesity have become a significant public health challenge worldwide. Numerous studies showed that the gut microbiota is associated with the development of obesity, and the regulatory mechanisms mediating the relationship between gut microbiota and obesity have become an intense research area. Capsaicin is a vanilla amide alkaloid that is an active ingredient in pepper. Much research demonstrated the antiobesity activity of capsaicin. This article reviews recent research on the antiobesity mechanisms of capsaicin involving alterations of the gut microbial composition, reduction of intestinal permeability, and regulation of the microbiome-gut-brain axis. This summary will establish a basis for further developing capsaicin as an ingredient in medications and health products.
肥胖是一种全球性的流行病，影响着数百万人的生活和健康。肥胖的预防和治疗已成为全球范围内的重大公共卫生挑战。大量研究表明，肠道微生物群与肥胖的发生有关，而介导肠道微生物群与肥胖之间关系的调节机制已成为一个热门研究领域。辣椒素是一种香草酰胺生物碱，是辣椒中的一种活性成分。大量研究表明辣椒素有抗肥胖活性。本文综述了近年来关于辣椒素抗肥胖机制的研究，包括改变肠道微生物组成、降低肠道通透性和调节微生物群-肠道-大脑轴。这一综述将为进一步开发辣椒素作为药物和保健品的成分奠定基础。
