Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany; Center of Allergy and Environment (ZAUM), Helmholtz Center and Technical University of Munich, Munich, Germany.
Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany; Division of Dermatology and Venereology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Center for molecular medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden.
J Invest Dermatol. 2022 Mar;142(3 Pt B):804-810. doi: 10.1016/j.jid.2021.04.032. Epub 2021 Sep 16.
T cells are key drivers of autoimmunity in numerous noncommunicable inflammatory skin diseases by directly harming host tissue or through helping B cells in producing autoantibodies. Technological advances have contributed to identifying autoantigens, the Holy Grail of autoimmunity, in many inflammatory disorders of the skin. Novel therapeutic approaches such as chimeric (auto)antibody receptor T cells are a milestone on the way to finding individualized, well-tolerated, targeted therapies. This review summarizes the current knowledge on pathogenesis, immune response pattern‒related ontology, diagnostic approaches, and treatment options of autoimmune skin diseases.
T 细胞通过直接损害宿主组织或通过帮助 B 细胞产生自身抗体，成为众多非传染性炎症性皮肤病中自身免疫的关键驱动因素。技术进步有助于确定自身抗原，这是非传染性炎症性皮肤病自身免疫的“圣杯”。新型治疗方法，如嵌合（自身）抗体受体 T 细胞，是找到个体化、耐受性好、靶向治疗的一个里程碑。这篇综述总结了自身免疫性皮肤病的发病机制、与免疫反应模式相关的本体论、诊断方法和治疗选择的最新知识。
