成纤维细胞在非纤维化自身免疫性皮肤病中的作用。
Role of fibroblasts in nonfibrotic autoimmune skin diseases.
机构信息
Department of Dermatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610000, China.
Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
出版信息
Mol Med. 2024 Oct 17;30(1):178. doi: 10.1186/s10020-024-00949-x.
Autoimmune diseases, a disease characterized by immune imbalance caused by the human immune system mistakenly attacking its own components, include vitiligo, psoriasis and atopic dermatitis (AD). Previous studies on autoimmune diseases have focused mainly on immune cells, keratinocytes and endothelial cells. Fibroblasts, the main cells that secrete the extracellular matrix (ECM) in the dermis, have been studied thoroughly in terms of fibrosis and wound healing. However, an increasing number of studies have shown that fibroblasts play an important role in nonfibrotic autoimmune skin diseases. In this article, the previously reported role of fibroblasts in nonfibrous autoimmune skin diseases such as psoriasis, vitiligo and AD is summarized to provide new ideas for the treatment of this disease.
自身免疫性疾病是一种由人体免疫系统错误攻击自身成分引起的免疫失衡疾病，包括白癜风、银屑病和特应性皮炎（AD）。以前对自身免疫性疾病的研究主要集中在免疫细胞、角质形成细胞和内皮细胞上。成纤维细胞是真皮中分泌细胞外基质（ECM）的主要细胞，其在纤维化和伤口愈合方面已经得到了充分的研究。然而，越来越多的研究表明，成纤维细胞在非纤维性自身免疫性皮肤病中发挥着重要作用。本文总结了先前报道的成纤维细胞在银屑病、白癜风和 AD 等非纤维性自身免疫性皮肤病中的作用，为该疾病的治疗提供了新思路。
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