Reid Jacqueline Kelsey, Kuipers Hedwich Fardau
Department of Clinical Neurosciences, Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.
Department of Cell Biology & Anatomy, Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.
Front Cell Neurosci. 2021 Sep 3;15:704884. doi: 10.3389/fncel.2021.704884. eCollection 2021.
Astrocyte heterogeneity is a rapidly evolving field driven by innovative techniques. Inflammatory astrocytes, one of the first described subtypes of reactive astrocytes, are present in a variety of neurodegenerative diseases and may play a role in their pathogenesis. Moreover, genetic and therapeutic targeting of these astrocytes ameliorates disease in several models, providing support for advancing the development of astrocyte-specific disease modifying therapies. This review aims to explore the methods and challenges of identifying inflammatory astrocytes, the role these astrocytes play in neurological disorders, and future directions in the field of astrocyte heterogeneity.
星形胶质细胞的异质性是一个由创新技术驱动的快速发展的领域。炎症性星形胶质细胞是最早被描述的反应性星形胶质细胞亚型之一，存在于多种神经退行性疾病中，并可能在其发病机制中发挥作用。此外，对这些星形胶质细胞进行基因和治疗靶向在多种模型中改善了疾病，为推进星形胶质细胞特异性疾病修饰疗法的发展提供了支持。本综述旨在探讨识别炎症性星形胶质细胞的方法和挑战、这些星形胶质细胞在神经系统疾病中的作用以及星形胶质细胞异质性领域的未来方向。
