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新鱼腥草素钠影响群体感应调控的转录组和毒力因子。

Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors of Controlled by Quorum Sensing.

作者信息

Zhao Yeye, Mei Longfei, Si Yuanqing, Wu Jiadi, Shao Jing, Wang Tianming, Yan Guiming, Wang Changzhong, Wu Daqiang

机构信息

Department of Pathogenic Biology and Immunology, College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.

Key Laboratory of Chinese Herbal Compound Formula in Anhui Province, Anhui University of Chinese Medicine, Hefei, China.

出版信息

Front Pharmacol. 2020 Oct 2;11:572375. doi: 10.3389/fphar.2020.572375. eCollection 2020.

DOI:10.3389/fphar.2020.572375
PMID:33123010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7566558/
Abstract

As a major opportunistic pathogen, can produce various virulence factors and form biofilms. These processes are controlled by the quorum sensing (QS) system. Sodium new houttuyfonate (SNH) is an adduct of houttuyfonate, the main component of the common Chinese medicine plant Houttuynia cordata, which has antibacterial and anti-inflammatory effects. We evaluated the effect of SNH on biofilms, virulence factors, and transcription. Transcriptome analysis showed that the key and genes of the QS system were down-regulated after SNH treatment. SNH reduces proteases and pyocyanin production and inhibits biofilm formation by regulating the QS system. SNH also changes the expression of genes related to virulence factors and biofilms (, and ). These results suggested that the mechanism of SNH against by affecting the expression of biofilm and virulence factors controlled by quorum sensing.

摘要

作为一种主要的机会性病原体，[病原体名称未给出]可产生多种毒力因子并形成生物膜。这些过程受群体感应（QS）系统控制。新鱼腥草素钠（SNH）是中药植物鱼腥草主要成分鱼腥草素的一种加成物，具有抗菌和抗炎作用。我们评估了SNH对[病原体名称未给出]生物膜、毒力因子和转录的影响。转录组分析表明，SNH处理后，QS系统的关键[基因名称未给出]和[基因名称未给出]基因下调。SNH通过调节QS系统减少蛋白酶和绿脓菌素的产生并抑制生物膜形成。SNH还改变与毒力因子和生物膜相关的基因（[基因名称未给出]、[基因名称未给出]和[基因名称未给出]）的表达。这些结果表明，SNH通过影响群体感应控制的生物膜和毒力因子的表达来对抗[病原体名称未给出]的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/c5afba96b993/fphar-11-572375-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/38de806eef57/fphar-11-572375-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/36271a7d2845/fphar-11-572375-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/0d2886491820/fphar-11-572375-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/9b2db1d63bae/fphar-11-572375-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/9d6f5c9aca54/fphar-11-572375-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/ebe469622001/fphar-11-572375-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/0c6357a010d1/fphar-11-572375-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/262af4897930/fphar-11-572375-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/c5afba96b993/fphar-11-572375-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/38de806eef57/fphar-11-572375-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/36271a7d2845/fphar-11-572375-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/0d2886491820/fphar-11-572375-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/9b2db1d63bae/fphar-11-572375-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/9d6f5c9aca54/fphar-11-572375-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/ebe469622001/fphar-11-572375-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/0c6357a010d1/fphar-11-572375-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/262af4897930/fphar-11-572375-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/7566558/c5afba96b993/fphar-11-572375-g009.jpg

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