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呼吸道合胞病毒或麻疹病毒感染神经元细胞后小非编码RNA的表达

Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells.

作者信息

Bakre Abhijeet A, Duffy Catherine, Abdullah Hani'ah, Cosby S Louise, Tripp Ralph A

机构信息

Department of Infectious Diseases, University of Georgia, Athens, GA, United States.

Virology Branch, Veterinary Sciences Division, Agri-Food and Biosciences Institute, Belfast, United Kingdom.

出版信息

Front Microbiol. 2021 Sep 3;12:671852. doi: 10.3389/fmicb.2021.671852. eCollection 2021.

DOI:10.3389/fmicb.2021.671852
PMID:34539595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8446675/
Abstract

Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression multiple mechanisms in neuronal cells.

摘要

呼吸道合胞病毒（RSV）或麻疹病毒（MeV）感染通过小非编码RNA（sncRNA）表达改变宿主反应。我们发现，神经元细胞感染RSV或MeV会诱导sncRNAs，包括各种微小RNA和转运RNA片段（tRFs）。我们表明，这些tRFs来源于特定的tRNAs（甘氨酸的GCC和CAC、缬氨酸的CTT和AAC以及赖氨酸的CCC和TTT）。如相对同义密码子使用指数所示，RSV或MeV很少使用其中一些tRNAs，这表明在受感染的神经元细胞中发生了tRNAs的选择性切割。数据表明，差异表达的sncRNAs可能通过多种机制调节神经元细胞中的宿主基因表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/d04064264f6e/fmicb-12-671852-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/b34ef429f602/fmicb-12-671852-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/bd5864eedb0d/fmicb-12-671852-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/f9b81ad160b2/fmicb-12-671852-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/3a8ee4d89a80/fmicb-12-671852-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/d04064264f6e/fmicb-12-671852-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/b34ef429f602/fmicb-12-671852-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/bd5864eedb0d/fmicb-12-671852-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/f9b81ad160b2/fmicb-12-671852-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/3a8ee4d89a80/fmicb-12-671852-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae9/8446675/d04064264f6e/fmicb-12-671852-g005.jpg

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