Vakhshoori Mehrbod, Heidarpour Maryam, Bondariyan Niloofar, Sadeghpour Niyousha, Mousavi Zohreh
Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Endocrinol. 2021 Sep 14;2021:2271514. doi: 10.1155/2021/2271514. eCollection 2021.
Coronavirus disease 2019 (COVID-19) manifestations varied completely from its time of emergence. However, the assessment of adrenal insufficiency (AI) in this pandemic is lacking. In this review, we aimed to evaluate the status of AI among COVID-19-infected individuals.
A systematic literature screening in PubMed/MEDLINE, Scopus, and Web of Science was performed until May 23, 2021. We collected relevant published peer-reviewed studies that reported AI occurrence in patients who suffered from COVID-19.
A total of 10 records (cross-sectional studies: 3, = 256, males: 176 (68.7%), and case reports: 7, = 7, males: 4 (57.1%)) were recruited. The age spectrum ranged from 22 to 96 years. AI was diagnosed with laboratory assessment or radiologic findings. The AI prevalence ranged from 3.1% to as high as 64.3% in different studies. Except for one patient, all other patients were discharged in stable conditions in published case reports.
This review indicates that AI occurrence in the COVID-19 pandemic seems quite probable; however, the extent and type (primary, secondary, and functional) need to be clarified yet. Appropriate early diagnostic and therapeutic interventions should be done, especially in critically ill patients, to prevent lethal outcomes.
2019年冠状病毒病（COVID-19）自出现以来表现各异。然而，目前缺乏对这一疫情中肾上腺功能不全（AI）的评估。在本综述中，我们旨在评估COVID-19感染者中AI的状况。
在PubMed/MEDLINE、Scopus和Web of Science中进行系统的文献筛选，直至2021年5月23日。我们收集了相关的已发表同行评审研究，这些研究报告了COVID-19患者中AI的发生情况。
共纳入10篇记录（横断面研究：3篇，n = 256，男性：176例（68.7%），病例报告：7篇，n = 7，男性：4例（57.1%））。年龄范围为22至96岁。AI通过实验室评估或影像学检查结果诊断。不同研究中AI的患病率从3.1%到高达64.3%不等。在已发表的病例报告中，除1例患者外，所有其他患者均病情稳定出院。
本综述表明，COVID-19疫情中发生AI似乎很有可能；然而，其程度和类型（原发性、继发性和功能性）仍需明确。应采取适当的早期诊断和治疗干预措施，尤其是对危重症患者，以防止致命后果。
