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[免疫功能正常的非洲黑人患者中模拟多灶性转移性结肠癌的多灶性肺结核:一例报告]

[Multifocal tuberculosis simulating multimetastatic colon cancer in an immunocompetent black African patient: a case report].

作者信息

Kpossou Aboudou Raïmi, Adjadohoun Sonia, Diallo Kadiatou, Badarou Salim, Ngamo Gabriel, Sokpon Comlan N'déhougbèa Martin, Vignon Rodolph Koffi, Takin Romulus, Yekpè Patricia, Sehonou Jean, Biaou Olivier

机构信息

Clinique Universitaire d'Imagerie Méficale, Centre National Hospitalier Universitaire Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Bénin.

Service de Médecine Interne, Hôpital Donka, Conakry, Guinée.

出版信息

Pan Afr Med J. 2021 Jul 2;39:167. doi: 10.11604/pamj.2021.39.167.26879. eCollection 2021.

DOI:10.11604/pamj.2021.39.167.26879
PMID:34539963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8434783/
Abstract

Multifocal tuberculosis is rare in immunocompetent subjects. It is characterized by the involvement of at least two extra-pulmonary sites, associated or not with lung disease. It is often difficult to diagnose. We here report a case of multifocal tuberculosis in a non-immunocompromised black African subject at the Hubert Koutoukou Maga National Hospital and University Center (CNHU-HKM) in Cotonou, Benin. The study involved a 23-year-old man, with no particular previous history, admitted with diffuse abdominal pain associated with alteration of general state. Clinical examination showed severe malnutrition and medium-volume ascites. Imaging tests (chest X-ray, ultrasound and computed tomography (CT) scan) showed multiple lung, liver, pancreatic, bone, lymph nodes and colic lesions suggesting multimetastatic tumor. Colonoscopy then showed budding lesion of the cecum. GeneXpert test showed Koch´s bacilli. The anatomo-pathological examination of colic biopsies and GeneXpert sputum test confirmed multifocal tuberculosis. The patient received antituberculosis treatment and nutritional support. However he died. Multifocal tuberculosis is a serious disease that is difficult to diagnose. Then it is frequently mis-diagnosed in tropical areas, especially when it occurs in immunocompetent patients.

摘要

多灶性结核病在免疫功能正常的人群中较为罕见。其特征是至少累及两个肺外部位,可伴有或不伴有肺部疾病。该病常难以诊断。我们在此报告一例在贝宁科托努的于贝尔·库图库·马加国家医院及大学中心(CNHU - HKM)发生的非免疫功能低下的非洲黑人多灶性结核病病例。该研究涉及一名23岁男性,既往无特殊病史,因弥漫性腹痛伴全身状况改变入院。临床检查显示严重营养不良和中等量腹水。影像学检查(胸部X线、超声和计算机断层扫描(CT))显示肺部、肝脏、胰腺、骨骼、淋巴结和结肠多处病变,提示多转移性肿瘤。随后结肠镜检查显示盲肠有芽状病变。GeneXpert检测显示结核杆菌。结肠活检的解剖病理学检查和GeneXpert痰检确诊为多灶性结核病。患者接受了抗结核治疗和营养支持。然而,他最终死亡。多灶性结核病是一种难以诊断的严重疾病。因此,在热带地区该病常被误诊,尤其是在免疫功能正常的患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac9b/8434783/543a070d3c11/PAMJ-39-167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac9b/8434783/ba50e0414f4d/PAMJ-39-167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac9b/8434783/a01ca026720d/PAMJ-39-167-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac9b/8434783/ba50e0414f4d/PAMJ-39-167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac9b/8434783/a01ca026720d/PAMJ-39-167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac9b/8434783/a791aa75e1dd/PAMJ-39-167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac9b/8434783/48004eeb79a6/PAMJ-39-167-g004.jpg
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Abdominal Tuberculosis Mimicking Cancer Clinically and on Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET) Imaging: A Two-Case Series.临床及氟脱氧葡萄糖(FDG)-正电子发射断层扫描(PET)成像表现酷似癌症的腹部结核:两例病例系列报道
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[Multifocal tuberculosis in immunocompetent patients].免疫功能正常患者的多灶性结核病
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Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.
孟德尔式分枝杆菌病易感性:IFN-γ免疫先天性缺陷的遗传、免疫和临床特征
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Isolated pancreatic tuberculosis mimicking inoperable pancreatic cancer: a diagnostic challenge resolved using endoscopic ultrasound-guided fine-needle aspiration.酷似无法手术切除的胰腺癌的孤立性胰腺结核:通过内镜超声引导下细针穿刺活检解决诊断难题
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