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Risk factors and molecular features of sequence type (ST) 131 extended-Spectrum-β-lactamase-producing Escherichia coli in community-onset female genital tract infections.社区获得性女性生殖道感染中携带扩展型β-内酰胺酶的大肠杆菌 131 型（ST131）的危险因素和分子特征。
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Genetic characterization of ESBL-producing and ciprofloxacin-resistant from Belgian broilers and pigs.比利时肉鸡和猪中产超广谱β-内酰胺酶（ESBL）及耐环丙沙星菌株的基因特征分析
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3
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本文引用的文献

1
Quinolone antibiotics.喹诺酮类抗生素
Medchemcomm. 2019 Jun 28;10(10):1719-1739. doi: 10.1039/c9md00120d. eCollection 2019 Oct 1.
2
Impact of co-existence of PMQR genes and QRDR mutations on fluoroquinolones resistance in Enterobacteriaceae strains isolated from community and hospital acquired UTIs.肠杆菌科菌株中同时存在 PMQR 基因和 QRDR 突变对社区获得性和医院获得性尿路感染中氟喹诺酮类药物耐药性的影响。
BMC Infect Dis. 2019 Nov 21;19(1):979. doi: 10.1186/s12879-019-4606-y.
3
Lower Urinary Tract Infections: Management, Outcomes and Risk Factors for Antibiotic Re-prescription in Primary Care.下尿路感染：基层医疗中抗生素再处方的管理、结局及危险因素
EClinicalMedicine. 2019 Aug 12;14:23-31. doi: 10.1016/j.eclinm.2019.07.012. eCollection 2019 Sep.
4
O25b-ST131 and O16-ST131 causing urinary tract infection in women in Changsha, China: molecular epidemiology and clinical characteristics.引起中国长沙女性尿路感染的O25b-ST131和O16-ST131：分子流行病学与临床特征
Infect Drug Resist. 2019 Aug 30;12:2693-2702. doi: 10.2147/IDR.S212658. eCollection 2019.
5
Trends in South Korean antimicrobial use and association with changes in Escherichia coli resistance rates: 12-year ecological study using a nationwide surveillance and antimicrobial prescription database.韩国抗菌药物使用趋势及其与大肠杆菌耐药率变化的关系：使用全国性监测和抗菌药物处方数据库进行的 12 年生态学研究。
PLoS One. 2018 Dec 31;13(12):e0209580. doi: 10.1371/journal.pone.0209580. eCollection 2018.
6
Risk Factors and Molecular Features of Sequence Type (ST) 131 Extended-spectrum β-Lactamase-producing Escherichia coli in Community-onset Bacteremia.社区获得性血流感染中产 ESBL 大肠埃希菌 ST131 型的危险因素和分子特征。
Sci Rep. 2017 Nov 7;7(1):14640. doi: 10.1038/s41598-017-14621-4.
7
Epidemic Emergence in the United States of Escherichia coli Sequence Type 131-30 (ST131-30), 2000 to 2009.2000年至2009年美国大肠杆菌序列类型131-30（ST131-30）的流行情况
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00732-17. Print 2017 Aug.
8
Plasmid-mediated quinolone resistance in Enterobacteriaceae: a systematic review with a focus on Mediterranean countries.肠杆菌科细菌中质粒介导的喹诺酮耐药性：一项聚焦地中海国家的系统评价
Eur J Clin Microbiol Infect Dis. 2017 Mar;36(3):421-435. doi: 10.1007/s10096-016-2847-x. Epub 2016 Nov 26.
9
Plasmid-Mediated Quinolone-Resistance () Genes in Clinical Isolates of Collected from Several Hospitals of Qazvin and Zanjan Provinces, Iran.从伊朗加兹温省和赞詹省多家医院收集的临床分离株中的质粒介导喹诺酮抗性（）基因
Osong Public Health Res Perspect. 2016 Oct;7(5):307-312. doi: 10.1016/j.phrp.2016.08.003. Epub 2016 Aug 24.
10
Fosfomycin, interesting alternative drug for treatment of urinary tract infections created by multiple drug resistant and extended spectrum β-lactamase producing strains.磷霉素，是一种用于治疗由多重耐药和产超广谱β-内酰胺酶菌株引起的尿路感染的有趣的替代药物。
Iran J Microbiol. 2016 Apr;8(2):125-31.

从患有尿路感染的女性中分离出的具有超广谱β-内酰胺酶（ESBL）表型的菌株中，ST131和非ST131克隆之间环丙沙星耐药基因的分布情况。

Distribution of ciprofloxacin-resistance genes among ST131 and non-ST131 clones of isolates with ESBL phenotypes isolated from women with urinary tract infection.

作者信息

Rasoulinasab Masoumeh, Shahcheraghi Fereshteh, Feizabadi Mohammad Mehdi, Nikmanesh Bahram, Hajihasani Azade, Aslani Mohammad Mehdi

机构信息

Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Microbiol. 2021 Jun;13(3):294-302. doi: 10.18502/ijm.v13i3.6389.

DOI:10.18502/ijm.v13i3.6389
PMID:34540167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8416580/
Abstract

BACKGROUND AND OBJECTIVES

sequence type 131 (ST131) is associated with extended-spectrum beta-lactamase (ESBL) production and fluoroquinolone resistance. This study aimed to investigate the prevalence of ST131, ESBL, and plasmid-mediated quinolone resistance (PMQR) genes in the ciprofloxacin-resistant (CIP) and ESBL producers from women with UTI.

MATERIALS AND METHODS

The CIP-resistant ESBL producing (CIP/ESBL) isolates were screened for ST131-by specific PCR of and . The ESBL and PMQR genes were screened by single PCR. The ST131 and non-ST131 isolates were selected to determine the mutations of and using PCR and sequencing, and also their genetic background by the Pasteur-MLST scheme.

RESULTS

Overall, 55% (33/60) CIP/ESBL isolates were identified as ST131 (94% O25b-ST131). Resistance rate to ampicillin-sulbactam (70%), aztreonam (97%) and gentamicin (61%), the prevalence of (66%), (82%), the profile of (30%), and the double mutation in the was significantly higher in ST131 than non- ST131 isolates. The coexistence of PMQR and ESBL genes was found in more than 50% of ST131 and non-ST131 isolates. ST131 isolates differentiated into PST43 and PST506.

CONCLUSION

Management of women with UTI caused by the CIP/ESBL isolates (ST131) co-harbored PMQR, ESBL, and chromosomal mutations, is important for their effective therapy.

摘要

背景与目的

131型序列（ST131）与超广谱β-内酰胺酶（ESBL）的产生及氟喹诺酮耐药性相关。本研究旨在调查泌尿道感染女性患者中耐环丙沙星（CIP）及产ESBL菌株的ST131、ESBL和质粒介导喹诺酮耐药（PMQR）基因的流行情况。

材料与方法

通过针对 和 的特异性PCR对耐CIP产ESBL（CIP/ESBL）分离株进行ST131筛查。通过单重PCR筛查ESBL和PMQR基因。选择ST131和非ST131分离株，采用PCR和测序确定 和 的突变情况，并通过巴斯德多位点序列分型方案确定其遗传背景。

结果

总体而言，55%（33/60）的CIP/ESBL分离株被鉴定为ST131（94%为O25b-ST131）。ST131分离株对氨苄西林-舒巴坦（70%）、氨曲南（97%）和庆大霉素（61%）的耐药率、 （66%）、 （82%）的流行率、 的分布情况（30%）以及 中的双重突变均显著高于非ST131分离株。超过50%的ST131和非ST131分离株中发现了PMQR和ESBL基因共存。ST131分离株分为PST43和PST506。

结论

对于由同时携带PMQR、ESBL和染色体突变的CIP/ESBL分离株（ST131）引起的女性泌尿道感染进行管理，对有效治疗至关重要。