Artanti Dita, Sari Yeti Eka Sispita, Azizah Fitrotin, Puwaningsih Nur Vita, Rohmayani Vella, Nasrullah Dede
Departement of Microbiology, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, Indonesia.
Departement of Clinical Pathology, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, Indonesia.
Iran J Microbiol. 2021 Jun;13(3):381-388. doi: 10.18502/ijm.v13i3.6401.
In 2020 the whole world is experiencing a pandemic condition due to infection with the SARS-CoV-2 virus which can cause the COVID-19 disease. This condition results in "Panic Buying", because everyone tries to avoid the spread and transmission of the COVID-19 disease by doing various ways, one of which is by taking additional supplements such as vitamin C and probiotic supplements.
The materials used were mice male DDY strain aged 1-2 months. Probiotic supplement La-14 with a viability of 1 × 10 CFU/ml. with a weight of 0.16 grams dissolved in 0.25 ml 0.9% NaCl. Vitamin C used is a commercial vitamin C tablet, weighing 0.06 grams in 0.25 ml 0.9% NaCl. Meanwhile, the feed for mice is a complete feed from Pokphand with the code BR1 CP511B. Lung histology preparations data were analysed descriptively and statistically through the test while the data on the number of lymphocytes were analysed descriptively.
The histological observations of lungs of showed that in the treatment of ML, MV, and MKA test was carried out ratio between the groups that did not have lymphocyte infiltration and those that had lymphocyte infiltration showed a significant difference (p <0.05). Meanwhile, the results of the lymphocyte count showed that ML and MV treatment was higher than that of MK treatment.
It is suggested that the administration of probiotics can stimulate and modulate the respiratory immune system.
2020年，全世界都在经历由感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引发的大流行状况，该病毒可导致新冠肺炎疾病。这种状况引发了“恐慌性抢购”，因为每个人都试图通过各种方式避免新冠肺炎疾病的传播，其中一种方式是服用额外的补充剂，如维生素C和益生菌补充剂。
所使用的材料为1至2月龄的雄性DDY品系小鼠。益生菌补充剂为活力为1×10 CFU/ml的La-14，0.16克溶于0.25毫升0.9%氯化钠中。所使用的维生素C是市售维生素C片，0.06克溶于0.25毫升0.9%氯化钠中。同时，小鼠饲料是正大集团的全价饲料，代码为BR1 CP511B。肺组织学切片数据通过检验进行描述性和统计学分析，而淋巴细胞数量数据进行描述性分析。
小鼠肺部的组织学观察表明，在ML、MV和MKA治疗组中，未发生淋巴细胞浸润的组与发生淋巴细胞浸润的组之间的比例存在显著差异（p<0.05）。同时，淋巴细胞计数结果表明，ML和MV治疗组高于MK治疗组。
建议服用益生菌可刺激和调节呼吸道免疫系统。
