Department of Obstetrics and Gynecology, Chongqing Renji Hospital, University of Chinese Academy of Sciences, Chongqing 401120, China.
Department of Pediatric Center, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China.
J Healthc Eng. 2021 Sep 6;2021:3911998. doi: 10.1155/2021/3911998. eCollection 2021.
To see whether serum glycocholic acid (CG) and total bile acids (TBA) can predict maternal and perinatal outcomes in pregnant women with intrahepatic cholestasis (ICP).
The observation group consisted of 80 women with ICP who were treated in our hospital, whereas the control group consisted of 50 ordinary women who were also treated at our hospital at the same time. The levels of CG and TBA in the two groups were determined independently, and the differences in poor perinatal outcomes were compared. Finally, the predictive diagnostic value of CG and TBA for poor perinatal outcomes in ICP mothers was displayed using the Spearman correlation between CG and TBA and Apgar. The maternal CG and TBA levels in the observation group were substantially higher than in the control group (P0.05). The observation group had more significant maternal-fetal discomfort, neonatal asphyxia, preterm birth, and perinatal death than the control group (P0.05). The risk of poor perinatal outcomes in ICP mothers rose when TBA and CG levels increased (P0.05). Apgar ratings were inversely associated with CG and TBA ( = -0.8251 and = -0.5969, respectively, P0.05). The CG and TBA diagnostic AUCs for unfavorable perinatal outcomes in ICP mothers were (P0.05).
CG and TBA have a high diagnostic value for ICP and may better predict and identify poor prenatal outcomes. It is suitable for clinical use.
观察血清甘胆酸（CG）和总胆汁酸（TBA）能否预测妊娠期肝内胆汁淤积症（ICP）孕妇的母婴结局。
观察组为我院收治的 80 例 ICP 患者，对照组为同期我院收治的 50 例普通患者。分别独立测定两组 CG 和 TBA 水平，比较两组不良围产结局的差异。最后用 Spearman 相关分析 CG、TBA 与 Apgar 之间的相关性，显示 CG、TBA 对 ICP 孕妇不良围产结局的预测诊断价值。
观察组孕妇 CG、TBA 水平明显高于对照组（P0.05）。观察组孕妇与胎儿不适、新生儿窒息、早产、围产儿死亡的发生率均明显高于对照组（P0.05）。随着 TBA、CG 水平升高，ICP 孕妇不良围产结局的风险升高（P0.05）。Apgar 评分与 CG、TBA 呈负相关（ = -0.8251、 = -0.5969，均 P0.05）。CG、TBA 对 ICP 孕妇不良围产结局的诊断 AUC 均大于 0.7（P0.05）。
CG、TBA 对 ICP 具有较高的诊断价值，可能更好地预测和识别不良产前结局，适合临床应用。
